D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE D-苏式-鞘胺醇-1-磷酸
CAS 26993-30-6 MFCD00270077
化学结构图
SMILES: [3H][C@@](O)(/C=C/CCCCCCCCCCCCC)[C@@H](N)COP(O)(O)=O
化学属性
| Mol. Weight | 379.47 |
|---|---|
| Mol. Formula | C18H38NO5P |
别名和识别编码
| Synonym | (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate D-erythro-Sphingosine 1-phosphate D-erythro-Sphingosine 1-phosphate |
|---|---|
| MDL Number | MFCD00270077 |
| PubChem Substance ID | 24899853 |
| CAS Number | 26993-30-6 |
| Chemical Name | D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE |
| Chemical Name Translation | D-苏式-鞘胺醇-1-磷酸 |
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分类
- Angiogenesis, Angiogenic Factors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Lipids, Lipids in Cell Signaling, Me
- {SNA} Angiogenic Factors, Bioactive Small Molecule Alphabetical Index, Lipids in Cell Signaling,
相关文献及参考
- [2]. Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal. 2002 Nov;14(11):941-53.
- [3]. S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94
- Byfield, F.J., et al., Cathelicidin LL-37 Peptide Regulates Endothelial Cell Stiffness And Endothelial Barrier Permeability. Am. J. Physiol. Cell Physiol. 300 , C105-12, (2011) 摘要
- Mattie, M., et al., Sphingosine-1-phosphate: a putative second messenger mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J. Biol. Chem. 269 , 3181, (1994)
- Panetti, T.S., Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. Biochim. Biophys. Acta 1582 , 190-196, (2002) 摘要
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安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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