1"-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4"-piperidin]-2(1H)-one 1"-(4-(三氟甲基)苯乙基)螺[苯并[d][1,3]恶嗪-4,4"-哌啶]-2(1H)-酮
CAS 300815-41-2 MFCD08703093
化学结构图
SMILES: Cl.O=C1NC2C=CC=CC=2C2(CCN(CCC3C=CC(=CC=3)C(F)(F)F)CC2)O1
化学属性
| Mol. Formula | C21H21F3N2O2· HCl |
|---|---|
| Mol. Weight | 426.86 |
别名和识别编码
| Chemical Name | 1"-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4"-piperidin]-2(1H)-one |
|---|---|
| Synonym | 1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-peperidin]-2(1H)-one |
| MDL Number | MFCD08703093 |
| PubChem Substance ID | 24724588 |
| Chemical Name Translation | 1"-(4-(三氟甲基)苯乙基)螺[苯并[d][1,3]恶嗪-4,4"-哌啶]-2(1H)-酮 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones
- {SA} Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones
- {SNA} Chemokine Inhibitors, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.
- [3]. Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6.
- [1]. Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
- [1]. Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
- [2]. Park J, et al. MCP-1/CCR2 system is inv
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