N-Methyl-N-propargylbenzylamine Hydrochloride 帕吉林盐酸盐

CAS 306-07-0 MFCD00012492

化学结构图

306-07-0
SMILES: C#CCN(C)Cc1ccccc1.Cl

化学属性

Mol. FormulaC11H14ClN
Mol. Weight196
Melting Point160-163 °C(lit.)

别名和识别编码

Chemical NameN-Methyl-N-propargylbenzylamine Hydrochloride
Synonym N-甲基-N-丙炔基苄胺 盐酸盐 Pargyline chloride USAF A-19120 N-Methyl-N-(2-propynyl)benzylamine hydrochloride Benzylmethylpropynylamine hydrochloride N-甲基-N-2-丙炔基苄胺 盐酸盐 N-甲基-N-丙炔基苄胺 盐酸盐 优降宁 盐酸盐 2-Propynylamine, N-benzyl-N-methyl-, hydrochloride MO 911 巴吉林盐酸盐,丙炔甲基苄胺,帕吉林,巴吉林 A 19120 N-Benzyl-N-methyl-2-propynylamine hydrochloride N-甲基-N-2-丙炔基苄胺 盐酸盐 优降宁 Pargyline hydrochloride Eudatin
CAS Number306-07-0
PubChem Substance ID9373
EC Number206-175-1
Beilstein Registry Number3699487
MDL NumberMFCD00012492
Chemical Name Translation帕吉林盐酸盐
Wiswesser Line Notation1UU2N1&1R &GH
LabNetwork Molecule IDLN01289095
InChIInChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
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分类

  • Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epigenetics, Histone Lysine Demethylase Inhibitors, Histone Methylation Modulators, L to O, Molecular Biology, Monoamine Oxidase B, Monoamine oxidase inhibitor, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, P
  • {SNA} Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
  • {SNA} Bioactive Small Mol

产品应用

  • 具有明显的降压作用，单胺氧化酶(MAO-B)选择性抑制剂。

相关文献及参考

  • Merck 14 ,7038
  • Yang, W., et al., Inhibition Of Semicarbazide-sensitive Amine Oxidase Attenuates Myocardial Ischemia-reperfusion Injury In An In Vivo Rat Model. Leuk. Res. 88 , 302-6, (2011) 摘要
  • Merck: 14,7038
  • Merck: 14,7038 Beilstein: 12,II,548

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
RTECSDP6650000
Precautionary statements
  • P301+P310
Signal word Danger
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition -20℃保存 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1500 ug/kg/D
TO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Nutritional

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 107,1068,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature increase
   Behavioral - changes in motor activity (specific assay)
   Biochemical - Neurotransmitters or modulators (putative) - catecholamine
   levels in CNS
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 107,1068,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 26,232,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 12 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JOENAK Journal of Endocrinology.  (Biochemical Soc. Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1939-
   Volume(issue)/page/year: 27,147,1963

其他信息

  • 有特异臭。易溶于水。水溶液不稳定，3.18％溶液为等渗溶液。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Monoamine oxidase inhibitor - L to O
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Epigenetics - Molecular Biology
  4. Bioactive Small Molecules for Epigenetic Research - Epigenetics
  5. Histone Methylation Modulators - Bioactive Small Molecules for Epigenetic Research
  6. Histone Lysine Demethylase Inhibitors - Histone Methylation Modulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type

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