Hygromycin B From Streptomyces Hygroscopicus 潮霉素B

CAS 31282-04-9 MFCD06795479

化学结构图

31282-04-9
SMILES: CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@]4(O[C@@H]([C@H](O)[C@H](O)[C@H]4O)[C@H](N)CO)O[C@H]23)[C@@H]1O

化学属性

Mol. FormulaC20H37N3O13
Mol. Weight528
Melting Point180

别名和识别编码

Chemical NameHygromycin B From Streptomyces Hygroscopicus
EC Number250-545-5
MDL NumberMFCD06795479
CAS Number31282-04-9
Beilstein Registry Number66457
PubChem Substance ID253661073
Synonym Hygromix-8 潮霉素 B 来源于吸水链霉菌 Hydromycin B Hygromix 2.4 Hygrovetine 潮霉素 B 溶液 来源于吸水链霉菌 Hygromycin B Antihelmycin
Chemical Name Translation潮霉素B
Reaxys-RN66457
Merck Number4852
LabNetwork Molecule IDLN01326597
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分类

  • Aminoglycosides, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics and Antimycotics, Antibiotics by Application,
  • {SNA} Aminoglycosides, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure Class, Core Bioreagents, Genetic Marker Selection, Interferes with Protein Synthesis, Life Science Reagents for Cloning, Mechanism of Action, Research Essentials, Spectrum of Activity, 抗生素, 生化试剂
  • {SNA} Aminoglycosides,

相关文献及参考

  • Nakagawa T, Kurose T, Hino T, Tanaka K, et. al., Development of series of gateway binary vectors, pGWBs, for realizing efficient construction of fusion genes for plant transformation. J. Biosci. Bioeng. 104 , 34-41, (2007) 摘要
  • Xi Y, Ge Y, Wang ZY., Genetic transformation of switchgrass. Methods Mol. Biol. , 53-59, (2009)
  • El-Shemy HA, Khalafalla MM, Ishimoto M., The role of green fluorescent protein (GFP) in transgenic plants to reduce gene silencing phenomena. Curr. Issues Mol. Biol. 11 , i21-i28, (2009) 摘要
  • Padilla IM, Burgos L., Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols. Plant Cell Rep. 29 , 1203-1213, (2010) 摘要
  • Dutt M, Grosser JW., An embryogenic suspension cell culture system for Agrobacterium-mediated transformation of citrus. Plant Cell Rep. 29 , 1251-1260, (2010) 摘要
  • Merck 14 ,4852

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T+ T
Hazard statements
  • H300+H310+H330
  • H318 Causes serious eye damage 严重伤害眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H301+H311
  • H330 Fatal if inhaled 吸入致命
RTECSWK2130000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P304+P340+P310
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P350
  • P405 Store locked up. 上锁保管。
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
Signal word
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S22 Do not breathe dust 不要吸入粉尘;
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R42/43
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Hazard Class6.1
UN Number
Storage condition 0-10°C
Packing GroupI
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(5),11,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 281,992,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46000 units/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 1,396,1967

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2220 ug/m3/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - aggression
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translat

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 3 gm/L
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 25,822,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 250 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 18,798,1980

系列性分类


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