2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine Maleate 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺马来酸盐
CAS 32795-47-4 MFCD00069320
化学结构图
SMILES: CN1CC2=C(N)C=CC=C2C(C1)C1C=CC=CC=1.OC(=O)/C=C\C(O)=O
化学属性
| Mol. Formula | C16H18N2· C4H4O4 |
|---|---|
| Mol. Weight | 354.40 |
别名和识别编码
| Chemical Name | 2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine Maleate |
|---|---|
| Synonym | 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, Alival (antidepressant) HOE 984 Hostalival Nomifensine maleate salt |
| MDL Number | MFCD00069320 |
| PubChem Substance ID | 24277920 |
| EC Number | 251-223-7 |
| Chemical Name Translation | 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺马来酸盐 |
| Wiswesser Line Notation | T66 CNT&J C1 ER& JZ &QV1U1VQ |
| CAS Number | 32795-47-4 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, N, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives
- {SNA} Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, N, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子,
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 854 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,45,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >32 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,45,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 66 mg/kg TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sen
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 600 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 28,171,1984
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