MAST CELL DEGRANULATING PEPTIDE
CAS 32908-73-9 MFCD00167557
化学结构图
SMILES: CC(C)[C@@H]1NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O
化学属性
| Mol. Formula | C110H192N40O24S4 |
|---|---|
| Mol. Weight | 2587.66 |
别名和识别编码
| Chemical Name | MCD peptide |
|---|---|
| Synonym | Mast cell degranulating peptide (honeybee) Mast cell degranulating peptide (honeybee reduced) cyclic MCD 肽 |
| MDL Number | MFCD00167557 |
| CAS Number | 32908-73-9 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channel Modulating Peptides, Ion Channels, M, Monovalent Ion Channels, Peptides and Proteins, Peptides for Cell Biology, Potassium Channel Modulators, Voltage-gated Ion Channels
相关文献及参考
- [2]. Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4.
- [1]. Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92.
- [1]. Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92.
- [2]. Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6800 ng/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
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