Tobramycin 妥布霉素
CAS 32986-56-4 MFCD00077885
化学结构图
SMILES: NC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](N)[C@@H]3O)[C@@H](N)C[C@H]2N)[C@@H](N)C[C@H]1O |&1:2,4,6,7,9,11,13,16,18,20,22,25,27,30|
化学属性
| Mol. Formula | C18H37N5O9 |
|---|---|
| Mol. Weight | 468 |
| Density | 1.52 |
| Refractive index | 143 |
| Melting Point | 178°C |
| Solubility | Soluble in water (94 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), methanol, and PBS (pH 7.2) (~10 mg/ml)., |
| Stability | 对湿度敏感 |
别名和识别编码
| Chemical Name | Tobramycin |
|---|---|
| CAS Number | 32986-56-4 |
| Synonym | Nebramycin 6 1-Epitobramycin Tobrex 3'-Deoxykanamycin B 妥布霉素; 妥布霉素; 硫酸妥布霉素; 托布霉素; 妥布霉素碱; O-3-氨基-3-脱氧-α-O-葡吡喃糖基-(1→6)-O-[2,6-二氨基-2,3,6-三脱氧-α-D-核-己吡喃糖基-(1→4)]-2-脱氧-D-链霉胺 Nebramycin VI Tobradistin O-3-Amino-3-deoxy-?-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-? -D-ribo-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine Tobramycin 妥布霉素 Nebramycin factor 6 Tobralex 妥布霉素，硫酸妥布霉素，托布霉素，妥布霉素碱，O-3-氨基-3-脱氧-alpha-O-葡吡喃糖基-(1→6)-O-[2 3 Obramycin Distobram Tobramax Tobramaxin Deoxykanamycin B 6-三脱氧-alpha-D-核-己吡喃糖基-(1→4)]-2-脱氧-D-链霉胺 Gernebcin 6-二氨基-2 |
| MDL Number | MFCD00077885 |
| Beilstein Registry Number | 1357507 |
| EC Number | 251-322-5 |
| PubChem Substance ID | 87560061 |
| Reaxys-RN | 1357507 |
| Merck Number | 9490 |
| Chemical Name Translation | 妥布霉素 |
| Wiswesser Line Notation | T6OTJ CZ EQ F1Z BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DZEQ F1Q |
| LabNetwork Molecule ID | LN01745230 |
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分类
- Oligosaccharides
- Pharmaceuticals
- Intermediates & Fine Chemicals,
- {SNA} Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity
产品应用
- Tobramycin is an aminoglycoside antibiotic.
相关文献及参考
- Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),
- Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972),
- Merck: 14,9490 Beilstein: 18,V,11,259
- Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >7500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 27,1467,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 445 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 2,100,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 440 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 27,1467,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 969 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,332,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 600 mg/kg SEX/DURATION : female 10-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - physical REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 12,19,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE : 600 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 23,1544,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 23,1544,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE : 150 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho
其他信息
- 妥布霉素属氨基糖苷类，白色或类白色吸湿性粉末。
- Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research.
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