10H-Phenothiazine-10-propanamine, N-[2-(4-morpholinyl)ethyl]-2-(trifluoromethyl)-, monohydrochloride

CAS 3772-70-1 MFCD N/A

化学结构图

3772-70-1
SMILES: Cl.FC(F)(F)c1ccc2c(c1)N(CCCNCCN1CCOCC1)c1ccccc1S2

化学属性

Mol. Weight510.49
Mol. FormulaC22H26F3N3OS.2ClH

别名和识别编码

Wiswesser Line NotationT C666 BN ISJ EXFFF B3N2&- AT6N DOTJ &GH 2
Chemical NameNDR 3680A
Synonym NDR-A 3680 2-Trifluoromethyl-10-(3-(beta-morpholinoethylamino)propyl)phenothiazine NDR 3680A
CAS Number3772-70-1
InChIKeyFUEQNNLRCBFOEH-UHFFFAOYSA-N
PubChem Substance ID462365
InChIInChI=1S/C22H26F3N3OS.ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)10-3-8-26-9-11-27-12-14-29-15-13-27;/h1-2,4-7,16,26H,3,8-15H2;1H
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安全信息

RTECSSP3325000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 616 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962

系列性分类

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