• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B,
• {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
• {SNA} Analytical Standards,
• {
• {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
• {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BA - BH, Bioactive Small Molecules, 细胞生物学
• {SNA} B, Bioactive Small Molecule Alphabetical Index, Corticosteroid,

产品应用

• 校准仪器和装置；评价方法；工作标准；质量保证/质量控制

相关文献及参考

• [2]. Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46.
• [3]. Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455.
• [4]. Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6.
• Beil. 8 ,IV,3501
• Corp MSDS 1 (1), 409:B / FT-IR 2 (3), 4234:B / RegBook 1 (2), 2863:M / Sax 6 , 426 / Sigma FT-IR 1 (1), 1200:D / Structure Index 1 , 458:B:8
• Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005),
• Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977),
• Li, A., et al.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 21,2117,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 ug/kg
SEX/DURATION            : female 18-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   PEREBL Pediatric Research.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1967-  Volume(issue)/page/year: 33,5,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 ug/kg
SEX/DURATION            : female 16-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JPEMAO Journal of Perinatal Medicine.  (Walter de Gruyter, Inc., 200 Saw
   Mill River Rd., Hawthorne, NY 10532)  V.1-    1973- Volume(issue)/page/year:
   22,319,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 18-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   DPTHDL Developmental Pharmacology and Therapeutics.  (S. Karger Pub., Inc.,
   79 Fifth Ave., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   18,14,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 600 ug/kg
SEX/DURATION            : female 20 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830

其他信息

• MOL 文件:378-44-9.mol
• Sigma Aldrich:378-44-9(sigmaaldrich)
• 图谱信息:倍他米松(378-44-9)核磁图( 13 CNMR) 倍他米松(378-44-9)质谱(MS) 倍他米松(378-44-9)红外图谱(IR1) 倍他米松(378-44-9)红外图谱(IR2)
• 毒性分级:中毒
• 激素类药物:倍他米松又称培他美松、贝皮质醇、贝氟美松、培氟美松，属于肾上腺皮质激素类药物，为地塞米松的同分异构体，作用与泼尼松龙和地塞米松相同，具有抗炎、抗风湿、抗过敏和抑制免疫等多种药理作用，抗炎作用较地塞米松、曲安西龙、氢化可的松等均强，可以减轻和防止组织对炎症的反应，消除局部非感染性炎症引起的发热、发红及肿胀，从而减轻炎症的表现，本品0.3mg的抗炎疗效与地塞米松0.75mg、泼尼松5mg或可的松25mg相当。 倍他米松的钠潴留作用为氢化可的松的百倍以上，在原发性肾上腺皮质功能减退症中，可与糖皮质类固醇一起用于替代治疗，防止或抑制细胞中介的免疫反应，延迟性的过敏反应，并减轻原发免疫反应的扩展，适用于低肾素低醛固酮综合征和植物神经病变所致体位性低血压等。 目前倍他米松还用于治疗活动性风湿病、类风湿性关节炎、红斑性狼疮、严重支气管哮喘、严重皮炎、急性白血病、过敏性皮炎、湿疹、神经性皮炎、脂溢性皮炎及瘙痒症和某些感染的综合治疗。 本品禁用于严重的精神病史，活动性十二指肠、胃溃疡，新近胃肠吻合术后，较重的骨质疏松，明显的糖尿病，严重的高血压，未能用抗菌药物控制的病毒、细菌、霉菌感染、血栓性静脉炎、感染性皮肤病，如脓疱病、体癣、股癣等。
• 上游原料:醋酸倍他米松
• 方法一:按美国专利3164618，将醋酸倍他米松于甲醇-氯仿-水的混合物中以盐酸处理，可使其转换为倍他米松。
• 储运特性:通风低温干燥
• 可燃性危险特性:可燃; 燃烧产生有毒氟化物烟雾
• 急性毒性:口服-小鼠 LD50: >;4500 毫克/公斤
• 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
• 类别:有毒物品
• 倍他米松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1837 倍他米松 Betamethasone 5G 1230元 2014/06/02 B1837 倍他米松 Betamethasone 1G 410元
• 用途一:激素类药。主要用于抗炎及抗过敏。适用于风湿性关节炎及各种皮肤病。倍他米松的作用同地塞米松，其抗炎作用比地塞米松、去炎松、氢化可的松强，副作用少。