1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) 1,2-二油酰-sn-甘油-3-磷酸乙醇胺

CAS 4004-05-1 MFCD00057986

化学结构图

4004-05-1
SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC

化学属性

Mol. FormulaC41H78NO8P
Mol. Weight744.03
Melting Point195-200°C

别名和识别编码

Chemical Name1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)
Synonym DOPE {LY} DOPE {} {LY} DOPE {} {} {LY} DOPE {} {} {} {LY} DOPE {} {} {} {} {LY} DOPE {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DOPE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00057986
Beilstein Registry Number1718431
CAS Number4004-05-1
PubChem Substance ID9546757
EC Number200-663-8
Chemical Name Translation1,2-二油酰-sn-甘油-3-磷酸乙醇胺
Reaxys-RN1718431
LabNetwork Molecule IDLN01310236
InChIInChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
Canonical SMILESO=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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分类

  • {SNA} Glycerophospholipid Metabolism, Glycerophospholipids, Glycerophosphonoethanolamines, Metabolic Pathways, 代谢组学, 生化试剂, 细胞生物学, 脂类
  • {SNA} Fluorescent Indicators and Probes, Glycerophosphoethanolamines, Glycerophospholipids, Lipophilic and Membrane Probes, Phospholipids,

相关文献及参考

  • 2. Shintou, K., et al., Interaction of an amphipathic peptide with phosphatidycholine/phosphatidylethanolamine mixed membranes Biophys. J. 93 , 3900-3906, (2007) 摘要
  • 3. LeSage, D., et al., Evaluation and optimization of DNA delivery into gliosarcoma 9L cells by a cholesterol-based cationic liposome. Biochim. Biophys. Acta 1564 , 393-402, (2002) 摘要
  • 4. Lai, L.W., et al., Kidney-targeted liposome-mediated gene transfer in mice Gene Ther. 4 , 426-431, (1997) 摘要
  • Scarzello, M., et al., Polymorphism of pyridinium amphiphiles for gene delivery: Influence of ionic strength, helper lipid content, and plasmid DNA complexation Biophys. J. 88 , 2104-2113, (2004) 摘要
  • Beil. 4 ,IV,1420

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P305+P351+P338
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Hazard statements
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H331 Toxic if inhaled 吸入中毒
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H302+H332
Signal word Danger Warning
Hazard Codes Xn
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R48/20/22
  • R38 Irritating to skin 刺激皮肤
  • R22 Harmful if swallowed 吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R20 Harmful by inhalation 吸入有害
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
UN Number 1888
Storage condition -20°C {LY} -20°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

系列性分类

  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Cloning and Expression - Molecular Biology
  4. Transfection & Transformation - Cloning and Expression
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Glycerophospholipid Metabolism - Metabolic Pathways
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Glycerophospholipids - Lipids
  5. Glycerophosphoethanolamines - Glycerophospholipids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Glycerophospholipids - Lipids
  5. Glycerophosphonoethanolamines - Glycerophospholipids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Indicators and Probes - Fluorescent Probes, Labels, Particles and Stains
  5. Lipophilic and Membrane Probes - Fluorescent Indicators and Probes
  6. Phospholipids - Lipophilic and Membrane Probes

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