1-(4-Chlorophenyl)Biguanide Hydrochloride 1-(4-氯苯基)双胍盐酸盐

CAS 4022-81-5 MFCD00053020

化学结构图

4022-81-5
SMILES: Cl.N=C(N)NC(=N)Nc1ccc(Cl)cc1

化学属性

Mol. FormulaC8H11Cl2N5
Mol. Weight248.11
Melting Point239-242 °C
TSCANo

别名和识别编码

Chemical Name1-(4-Chlorophenyl)Biguanide Hydrochloride
CAS Number4022-81-5
Alfabeta NameCHLOROPHENYLIMIDODICARBONIMIDICDIAMIDEHYDROCHLORIDE N4()--
MDL NumberMFCD00053020
Synonym 1-(4-Chlorophenyl)biguanide hydrochloride {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(4-Chlorophenyl)biguanide hydrochloride {} {} {} {} {} {} {}
PubChem Substance ID458746
EC Number000-000-0
Beilstein Registry Number3732533
Chemical Name Translation1-(4-氯苯基)双胍盐酸盐
Wiswesser Line NotationMUYZMYUM&MR DG &GH
InChIKeyNAFSLMFLGYXGIF-UHFFFAOYSA-N
LabNetwork Molecule IDLN00160792
InChIInChI=1S/C8H10ClN5.ClH/c9-5-1-3-6(4-2-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
Canonical SMILESC1=C(C=CC(=C1)NC(=N)NC(=N)N)Cl.Cl
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分类

  • Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {SNA} Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit significantly dihydrofolate reductase (DHFR).

相关文献及参考

  • Baccanari, D., et al.: Biochemistry, 21, 5068 (1982),
  • Ahrweiler, P., et al.: J. Bacteriol., 170, 3301 (1988),
  • Zolli-Juran, M., et al.: Bioorg. Med. Chem. Lett., 13, 2493 (2003),

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
RTECSDU1780200
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Hygroscopic 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04062

其他信息

  • 1-(4-氯苯基)双胍盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B20311 1-(4-氯苯基)双胍 盐酸盐, 97% 1-(4-Chlorophenyl)biguanide hydrochloride, 97% 5g 1540元 2010/05/25 B20311 1-(4-氯苯基)双胍 盐酸盐, 97% 1-(4-Chlorophenyl)biguanide hydrochloride, 97% 1g 337元
  • Sigma Aldrich:4022-81-5(sigmaaldrich)
  • Alfa Aesar:1-(4-氯苯基)双胍盐酸盐,97% 1-(4-Chlorophenyl)biguanide hydrochloride, 97%(4022-81-5)
  • Hazard Note:Irritant
  • MOL 文件:4022-81-5.mol
  • 敏感性:Hygroscopic

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds

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