Alpha-Methyldopa Sesquihydrate L-甲基多巴

CAS 41372-08-1 MFCD00149280

化学结构图

41372-08-1
SMILES: O.O.O.C[C@](N)(Cc1cc(O)c(O)cc1)C(O)=O.C[C@](N)(Cc1cc(O)c(O)cc1)C(O)=O

化学属性

Mol. Formula(HO)2C6H3CH2C(CH3)(NH2)CO2H
Mol. Weight238
Melting Point>;300 °C(lit.)
TSCANo

别名和识别编码

Chemical NameAlpha-Methyldopa Sesquihydrate
MDL NumberMFCD00149280
Synonym Methyl dopa sesquihydrate (-)-3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 倍半水合物 α-甲基-L-多巴 L-α-甲基多巴 alpha-Methyldopa Hyperpax alpha-Methyl-L-DOPA
EC Number209-089-2
CAS Number41372-08-1
Merck Number14,6055
InChIKeyYKFCISHFRZHKHY-NGQGLHOPSA-N
Chemical Name TranslationL-甲基多巴
PubChem Substance ID24888444
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分类

  • {SNA} Alanine Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Unnatural Amino Acids & Derivatives

相关文献及参考

  • [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.
  • [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
  • [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
  • [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.

安全信息

RTECSYP2860000
Storage condition Air & Light Sensitive
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 604 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-348,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2980 mg/kg
SEX/DURATION            : male 65 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-348,1989

系列性分类


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