Nimustine

CAS 42471-28-3 MFCD00866532

化学结构图

42471-28-3
SMILES: CC1N=CC(CNC(=O)N(CCCl)N=O)=C(N)N=1

化学属性

Mol. FormulaC9H13ClN6O2
Mol. Weight272.73

别名和识别编码

Chemical NameNimustine
Synonym 3-(4-Amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea Nimustine
CAS Number42471-28-3
Beilstein Registry Number0685903
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安全信息

RTECSYR8449000
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,1361,1987

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 8 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 75 ug/plate
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal o

TYPE OF TEST            : Mutation in microorga

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 2 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 149,95,1985

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 8 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,1361,1987

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 149,95,1985

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   YSKODB Yakubutsu, Seishin, Kodo.  Japanese Journal of Psychopharmacology.
   (Nippon Shinkei, Seishin Yakuri Gakkai, 1433 Nogawa, Miyamae-ku, Kawasaki,
   213, Japan)  V.1-    1981-  Volume(issue)/page/year: 11,438,1991

系列性分类


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