(S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride Nα-甲苯磺酰基-L-赖氨酸氯甲基酮盐酸盐

CAS 4272-74-6 MFCD00065395

化学结构图

4272-74-6
SMILES: Cc1ccc(S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl)cc1.Cl

化学属性

Mol. FormulaC14H21ClN2O3S · HCl
Mol. Weight369.31
Appearance powder
SolubilityH2O: 50 mg/mL
Melting Point~165 °C (dec.)

别名和识别编码

Chemical Name(S)-N-(7-Amino-1-Chloro-2-Oxoheptan-3-Yl)-4-Methylbenzenesulfonamide Hydrochloride
Synonym (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride TLCK Tosyl-L-lysyl-chloromethane hydrochloride (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride Benzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-, Chloromethane, Tosyllysyl Chloromethyl Ketone, Tosyllysine Chlorotosylamidoaminoheptanone Ketone, Tosyllysine Chloromethyl L-N-(5-Amino-1-(chloroacetyl)pentyl)-p-toluenesulfonamide hydrochloride Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride TLCK Tosyl-L-lysyl-chloromethane hydrochloride Tosyllysine Chloromethyl Ketone Tosyllysyl Chloromethane
MDL NumberMFCD00065395
PubChem Substance ID73093
Beilstein Registry Number7106867
CAS Number4272-74-6
EC Number224-266-4
Chemical Name TranslationNα-甲苯磺酰基-L-赖氨酸氯甲基酮盐酸盐
InChIKeyYFCUZWYIPBUQBD-ZOWNYOTGSA-N
InChIInChI=1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
LabNetwork Molecule IDLN01323275
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分类

  • Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers
  • {SA} A to C, Adenylate cyclase, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Bromelain, Cell Biology, Cell Signaling and Neuroscience, Clostripain, Coagulation Proteins and Reagents, Endoproteinase Arg-C, Endoproteinase Lys-C, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Ficin, P to Q, Papain, Peptides and Proteins,
  • {SNA} A to C, Adenylate c

相关文献及参考

  • Abate, A., and Schroder, H., Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-κB. Life Sci. 62 , 1081-1088, (1998) 摘要
  • Kwon, G., et al., Evidence for involvement of the proteasome complex (26S) and NFκB in IL-1β-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 47 , 583-591, (1998) 摘要
  • D'Acquisto, F., et al., Involvement of NF-κB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett. 418 , 175-178, (1997) 摘要
  • Grammer, T.C., , and Blenis, J., The serine protease inhibitors tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone potently inhibit pp 70s6k activation. J. Biol. Chem. 271 , 23650, (1996) 摘要
  • Stefanis, L., et al., Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death. J. Neurochem. 69 , 1425-1437, (1997) 摘要
  • Kwo, P., et al., Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes. Am. J. Physiol. 268 , G613-G621, (1995) 摘要
  • Bassindale, A.R., et al., Enzyme-catalysed siloxane bond formation. J. Inorg. Biochem. 96 , 401-6, (2003) 摘要
  • Peters, S., et al., Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability. Cytokine 40 , 144-50, (2007) 摘要

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSXT5160000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 150 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 19,95,1979

其他信息

  • MOL 文件:2364-87-6.mol
  • color:white to pink
  • F:10-21

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Adenylate cyclase - A to C
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Analytical Enzymes - Enzymes, Inhibitors, and Substrates
  5. Trypsin - Analytical Enzymes
  6. Trypsin Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Type
  6. Chelators

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