4-(4-Aminophenyl)Morpholin-3-One 4-(4-氨基苯基)吗啡啉-3-酮

CAS 438056-69-0 MFCD08236742

化学结构图

438056-69-0
SMILES: NC1=CC=C(C=C1)N1CCOCC1=O

化学属性

Mol. FormulaC10H12N2O2
Mol. Weight192
Melting Point171.0 to 175.0 deg-C

别名和识别编码

Chemical Name4-(4-Aminophenyl)Morpholin-3-One
CAS Number438056-69-0
Alfabeta NameAMINOPHENYLMORPHOLINONE 443()----
MDL NumberMFCD08236742
Synonym 4-(3-Oxo-4-morpholinyl)aniline 4-(4-Aminophenyl)morpholin-3-one
Chemical Name Translation4-(4-氨基苯基)吗啡啉-3-酮
PubChem Substance ID253659778
LabNetwork Molecule IDLN00160267
Reaxys-RN9482023
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分类

  • {KO} Anilines
  • Heterocycles
  • Pharmaceuticals
  • Amines
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Morpholines/Thiomorpholines
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • Reagent used in the preparation of various Morpholine based pharmaceuticals.

相关文献及参考

  • Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004),
  • Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005),

安全信息

Warnings IRRITANT
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Signal word

药物吸收、分布、代谢与排泄(ADME)

Lipinski's Rule of 3
Y
Lipinski's Rule of 5
Y
H-bond Acceptors
2
Rotatable Bonds
1
H-bond Donors
1
LogP
-9.629999999999998e-002

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  5. C4 to C10 - Morpholines/Thiomorpholines
  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. 利伐沙班中间体

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