Diphenyleneiodonium chloride 二亚苯基碘鎓氯化物

CAS 4673-26-1 MFCD00214165

化学结构图

4673-26-1
SMILES:

化学属性

Mol. FormulaC12H8ClI
Mol. Weight315
Melting Point312-322°C

别名和识别编码

Chemical NameDiphenyleneiodonium chloride
MDL NumberMFCD00214165
CAS Number4673-26-1
Synonym DPI Dibenziodolium chloride Diphenyleneiodonium chloride 氯化二亚苯基碘鎓
PubChem Substance ID24278032
Chemical Name Translation二亚苯基碘鎓氯化物
LabNetwork Molecule IDLN01286204
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分类

  • {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, DIG-DY, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, L to O, NOS Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase, Nitric Oxide Synthase Regulators, 一氧化氮代谢, 一氧化氮和细胞应激, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Cell Signaling Enzymes, DIG-DY, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
  • {SNA} Application Index,

产品应用

  • 有效并具可逆性的氧化氮合成酶抑制剂，来自于巨噬细胞和内皮细胞。该抑制剂也抑制其它的黄素酶（flavoenzymes）， 如中性粒细胞NADPH氧化酶。

相关文献及参考

  • [2]. He YF, et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21.
  • [1]. Suzuki H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94.
  • [1]. Suzuki H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94.
  • [2]. He YF, et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21.

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. DIG-DY - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkyl 烷基卤代烃
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Nitric Oxide Synthase - L to O
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Nitric Oxide Metabolism
  6. Nitric Oxide Scavengers
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Nitric Oxide Metabolism
  6. NO Donors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. NADH peroxidase
  1. Medical Research Areas
  2. Metabolism
  3. NADPH Oxidase  (NADPH氧化酶)
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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