8-(4-Dibenzothiophenyl)-2-(4-Morpholinyl)-4H-1-Benzopyran-4-One 8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮

CAS 503468-95-9 MFCD03468959

化学结构图

503468-95-9
SMILES: O=c1cc(N2CCOCC2)oc2c(-c3cccc4c3sc3ccccc34)cccc12

化学属性

Mol. Weight413.49
Mol. FormulaC25H19NO3S
Appearance Off-white to beige solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

CAS Number503468-95-9
Chemical Name8-(4-Dibenzothiophenyl)-2-(4-Morpholinyl)-4H-1-Benzopyran-4-One
Synonym 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788
Chemical Name Translation8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
FormulaC25H19NO3S
IUPAC Name8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
InChIKeyJAMULYFATHSZJM-UHFFFAOYSA-N
InChIInChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
Canonical SMILESO=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13
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分类

  • Heterocycles
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB.

相关文献及参考

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安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. DNA Damage
  3. DNA-PK
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. DNA-PK

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