(+)-Methamphetamine hydrochloride solution S-(+)-Methamphetamine

CAS 51-57-0 MFCD00056130

化学结构图

51-57-0
SMILES: CN[C@@H](C)Cc1ccccc1.Cl

化学属性

Mol. FormulaC10H15N.ClH
Mol. Weight185.72

别名和识别编码

Chemical NameHydrochloride
CAS Number51-57-0
Synonym {uni_hamburg} Philopon Drinalfa d-Desoxyephedrine hydrochloride Desoxyfed Dextim Methylisomyn Destim Gerovit Doxyfed (+)-Methamphetamine chloride Adipex Norodin hydrochloride d-Methylamphetamine hydrochloride Methamphetaminium chloride Soxysympamine (S)-N, α-dimethylbenzeneethanamine hydrochloride Efroxine Deofed Tonedron Pervitin N-Methylamphetamine hydrochloride Eufodrinal Syndrox Desoxyn Desyphed d-N-Methyl-beta-phenylisopropylamine hydrochloride Methylamphetamine hydrochloride Dexoval (+)-甲基苯丙胺 盐酸盐 溶液 d-Deoxyephedrine hydrochloride (?S)- (+)-Methamphetamine hydrochloride (S)-N, a-dimethylbenzene ethanamine hydrochloride methamphetamine hydrochloride Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (S)- d-Methamphetamine hydrochloride Isophen
PubChem Substance ID24896988
MDL NumberMFCD00056130
EC Number200-106-9
Wiswesser Line Notation1MY1R &GH
Chemical Name TranslationS-(+)-Methamphetamine
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; chiral; 2fragments; ionic
  • {SA} β-Glucuronidase, β-Glucuronidase Drug Analysis Bundle, Alphabetic, Amphetamine, Analytical Standards, Analytical and Industrial Enzymes, Analytical/Chromatography, Biochemicals and Reagents, Chemical Structure, Chromatography, Drug standards, Drugs & Metabolites, Drugs of Abuse, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, M, META - METH, Solutions
  • {SNA} β-Glucuronidase, β-Glucuronidase Drug Analysis Bundle, Alphabetical Index of Analytical Standards, Amphetamine, Analytical Standards,

产品应用

  • A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity.

相关文献及参考

  • Lands, M., et al.: J. Pharmacol. Exp. Ther., 89, 382 (1947),
  • Repke, D.B., et al.: J. Pharm. Sci., 67, 1167 (1978),
  • Pope, H.G., et al.: J. Clin. Psychiatry, 47, 339 (1986),
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
Precautionary statements
  • P301+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
RTECSSH5455000
Hazard Codes F,T
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
Restrict 精神药品
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
                          female 1-21 day(s) after conception
                          lactating female 19 day(s) post-birth
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
   EAGRDS Experimental Aging Research.  (Beech Hill Pub. Co., POB 136,
   Southwest Harbor, ME 04679) V.1-    1975-  Volume(issue)/page/year:
   5,509,1979

{hazard_com

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,346,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10930 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 253,466,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02170

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7560 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,214,1946

TYPE OF TEST            : LD

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 792 mg/kg
SEX/DURATION            : male 4 week(s) pre-mating
                          female 4 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JONRA9 Journal of Neurochemistry.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036) V.1-    1956-  Volume(issue)/page/year: 20,625,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 19 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   NHOZAX Nippon Hoigaku Zasshi.  Japanese Journal of Legal Medicine.  (Nippon
   Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo,
   Bunkyo-ku, Tokyo 113, Japan)  V.1-    1944-  Volume(issue)/page/year:
   46,126,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperito

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 17 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NHOZAX Nippon Hoigaku Zasshi.  Japanese Journal of Legal Medicine.  (Nippon
   Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo,
   Bunkyo-ku, Tokyo 113, Japan)  V.1-    1944-  Volume(issue)/page/year:
   46,126,1992

系列性分类


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