3-Methyladenine 6-氨基-3-甲基嘌呤

CAS 5142-23-4 MFCD00010531

化学结构图

5142-23-4
SMILES: Cn1cnc(N)c2ncnc1-2

化学属性

Mol. FormulaC6H7N5
Mol. Weight149.15
Density1.60
Melting Point300°C
Flash Point99°C
Boiling Point240.1°C at 760 mmHg
TSCANo
SolubilityDMSO 4 mg/mL Water <1 mg/mL Ethanol 4 mg/mL

别名和识别编码

Chemical Name3-Methyladenine
CAS Number5142-23-4
Synonym 3-Methyladenine {LY} 3-Methyladenine {} {LY} 3-Methyladenine {} {} {LY} 3-Methyladenine {} {} {} {LY} 3-Methyladenine {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methy
EC Number225-908-6
Beilstein Registry Number146087
MDL NumberMFCD00010531
PubChem Substance ID253660841
Chemical Name Translation6-氨基-3-甲基嘌呤
Reaxys-RN146087
InChIKeyFSASIHFSFGAIJM-UHFFFAOYSA-N
LabNetwork Molecule IDLN00331106
Canonical SMILESNC1=C2N=CN=C2N(C)C=N1
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分类

  • Bases & Related Reagents
  • {SNA} Autophagy, Autophagy Inhibitors, Biochemicals and Reagents, Cell Signaling and Neuroscience, Core Bioreagents, Nucleoside Analogs, Nucleosides and Nucleotides, Nucleosides, Nucleotides, Oligonucleotides, Research Essentials, 细胞生物学
  • Nucleotides
  • Inhibitors
  • Heterocycles
  • {SNA} Autophagy, Autophagy Inhibitors,

产品应用

  • 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concen

相关文献及参考

  • [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
  • [3]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 2016;2016:8369704.
  • Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006),
  • Hayat, M., et al.: Oncologist, 12, 20 (2007),
  • Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001),
  • [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
  • [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
  • [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
  • [3]. Wang X, et al. Acanthopanax

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P332+P313
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P305+P351+P338+P337+P313
RTECSAU6520000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 46(5),104,1983

系列性分类


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