(R)-2-(2-Fluoro-[1,1'-Biphenyl]-4-Yl)Propanoic Acid (R)-2-(2-氟-[1,1'-联苯]-4-基)丙酸
CAS 51543-40-9 MFCD00869714
化学结构图
SMILES: C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1
化学属性
| Mol. Formula | C15H13FO2 |
|---|---|
| Mol. Weight | 244 |
| Melting Point | 110-113 °C(lit.) |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (R)-2-(2-Fluoro-[1,1'-Biphenyl]-4-Yl)Propanoic Acid |
|---|---|
| Synonym | (R)-(-)-2-氟-α-甲基-4-联苯乙酸 (R)-2-氟比洛芬 氟比洛芬 E7869, E 7869, E-7869, Flurizan, Furbiprofen, MPC-7869, MPC 7869, MPC7869, (R)-Flurbiprofen |
| MDL Number | MFCD00869714 |
| PubChem Substance ID | 24878847 |
| EC Number | 257-264-7 |
| CAS Number | 51543-40-9 |
| Chemical Name Translation | (R)-2-(2-氟-[1,1'-联苯]-4-基)丙酸 |
| Formula | C15H13FO2 |
| IUPAC Name | (R)-2-(3-Fluoro-4-phenylphenyl)propanoic acid |
| InChIKey | SYTBZMRGLBWNTM-SNVBAGLBSA-N |
| InChI | InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1 |
| Canonical SMILES | C[C@H](C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(O)=O |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} Aryl Fluorinated Building Blocks, Asymmetric Synthesis, Building Blocks, C13-C26, Carboxylic Acids, Chemical Synthesis, Chiral Building Blocks, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
- {SNA} Aryl Fluorinated Building Blocks, Asymmetric Synthesis, Bioactive Small Molecules, Building Blocks, C13-C26, Carboxylic Acids, Cell Biology, Chemical Synthesis, Chiral Building Blocks, F, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks,
产品应用
- Tarenflurbil, also known as (R)-Flurbiprofen, is an orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. Tarenflurbil does not inhibit the enzyme cyclo-oxygenase. Tarenflurbil is currently tested in patients with mild Alzheimer's disease.
相关文献及参考
- [2]. Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287(39):32640-50.
- [3]. Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6(11):1398-422.
- [1]. You X, et al. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111(1):142-9.
- [1]. You X, et al. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111(1):142-9.
- [2]. Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287(39):32640-50.
- [3]. Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6(11):1398-422.
安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
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