Rel-(S)-(2,8-Bis(Trifluoromethyl)Quinolin-4-Yl)((R)-Piperidin-2-Yl)Methanol Hydrochloride rel-(S)-(2,8-双(三氟甲基)喹啉-4-基)((R)-哌啶-2-基)甲醇盐酸盐

CAS 51773-92-3 MFCD00797519

化学结构图

51773-92-3
SMILES: Cl.O[C@@H]([C@H]1CCCCN1)C1=CC(=NC2C(=CC=CC=21)C(F)(F)F)C(F)(F)F |&1:2,3|

化学属性

Mol. FormulaC17H16F6N2O·HCl
Mol. Weight414.78

别名和识别编码

Chemical NameRel-(S)-(2,8-Bis(Trifluoromethyl)Quinolin-4-Yl)((R)-Piperidin-2-Yl)Methanol Hydrochloride
Synonym (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride Mefloquine hydrochloride WR 14249 WR 142490 dl-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride
MDL NumberMFCD00797519
PubChem Substance ID160871289
EC Number257-412-0
Reaxys-RN5203544
CAS Number51773-92-3
Merck Number5801
Chemical Name Translationrel-(S)-(2,8-双(三氟甲基)喹啉-4-基)((R)-哌啶-2-基)甲醇盐酸盐
Wiswesser Line NotationT66 BNJ CXFFF EYQ- BT6MTJ& JXFFF &GH
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Fluorination Ready Pharma-Developed Compounds, M, Roche, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Fluorination Ready Pharma-Developed Compounds, M, Merck, Roche, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,

相关文献及参考

  • [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545.
  • [3]. Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403.
  • [4]. Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.
  • [1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.
  • [1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.
  • [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
RTECSVC0308000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SP

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ACTRAQ Acta Tropica.  (Schwabe & Co., Steintorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 37,232,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 880 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ACTRAQ Acta Tropica.  (Schwabe & Co., Steintorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 37,232,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 96 mg/kg/52D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Behavioral - aggression
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 154,2360,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 11 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   114,994,199

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Adhesion Molecules and Related Proteins - Cytoskeleton and Extracellular Matrix
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

相关产品推荐