Morphine hydrochloride [USP:JAN]

CAS 52-26-6 MFCD00069309

化学结构图

52-26-6
SMILES: CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O=S(=O)(O)O

化学属性

Mol. FormulaC17H19NO3.ClH
Mol. Weight321.83

别名和识别编码

Chemical NameMorphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl-, hydrochloride,(5-alpha,6-alpha)-
EC Number200-659-6
MDL NumberMFCD00069309
Synonym Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, Ampek 吗啡 硫酸盐 溶液
InChIKeyXCKKIKBIPZJUET-VYKNHSEDSA-N
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JQ P1&GH
CAS Number52-26-6
PubChem Substance ID5464110
InChIInChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Alkaloids, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs of Abuse, Drugs of Abuse: European Offering, Forensic and Veterinary Standards, M, METI - MZ, Morphine, Solutions

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P301+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard Codes F,T
Risk Statements
  • R11 Highly flammable 非常易燃
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
RTECSQC8575000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 148 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   73,887,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 7,372,1959

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 398 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 66,182,1939

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   5,175,1973

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 21 ?  after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
   EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya.  Experimental and
   Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
   Moscow, Russia)  V.55-    1992-  Volume(issue)/page/year: 58(6),42,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 840 mg/kg
SEX/DURATION            : female 4-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   KAEMAW Kitasato Archives of Experimental Medicine.  (Kitasato Institute,
   5-9-1 Shirokane, Minato-ku, Tokyo 108, Japan)  V.1-    1917-
   Volume(issue)/page/year: 51,41,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ENDKAC Endokrinologie.  (Leipzig, Ger. Dem. Rep.)  V.1-80, 1928-82.  For
   publisher information, see EXCEDS.  Volume(issue)/page/year: 40,152,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic

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