Angelicin 异补骨脂素

CAS 523-50-2 MFCD00064930

化学结构图

523-50-2
SMILES: O=c1ccc2ccc3occc3c2o1

化学属性

Mol. FormulaC11H6O3
Mol. Weight186
Density1.389
Melting Point138.0 to 142.0 deg-C
Boiling Point104°C/4mmHg(lit.)

别名和识别编码

Chemical NameAngelicin
MDL NumberMFCD00064930
CAS Number523-50-2
Synonym 2-OXO-[2H]-FURO[2,3-H]-1-BENZOPYRAN 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 2h-furo(2,3-h)(1)benzopyran-2-one 2h-furo(2,3-h)-1-benzopyran-2-one 3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone 3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidgamma-lactone 4-hydroxy-5-benzofuranacrylicacidgamma-lactone ANGELICIN ANGELICINE hplc Angecin Angelicin Furo(5',4',7,8)coumarin ISOPSORALEN ISOPSORALENE Isopsoralen （Angelicin） NSC 404563 angecin angelicin furo(2,3-h)coumarin isopsoralen 异补骨脂素 异补骨酯素 异香柠檬烯
PubChem Substance ID10658
Reaxys-RN153970
EC Number250-023-7
Beilstein Registry Number153970
Chemical Name Translation异补骨脂素
Wiswesser Line NotationT B566 EO LVOJ
LabNetwork Molecule IDLN00202465
InChIInChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
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分类

  • {SNA} AN-AZ, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA metabolism, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analytical Standards, Analytical/Chromatography, Angelica, Chromatography, Life Sciences Standards, Phytopharma Standards, Pimpinella, Standards by Plant Genus
  • {SNA} A - D, Alphabetical, Analytical Standards, Angelica, Phytochemical Standards,
  • {SNA} Apoptosis and Cell Cycle, DNA Intercalators and Crosslinkers, DNA metabolism, 细胞信号转导和神经科学, 细胞生物学

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P302+P350
  • P302+P352
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
RTECSLV0940000
Signal word
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition -20°C 2-8°C -20 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 165 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Behavioral - analgesia
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 63,833,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 254 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Behavioral - analgesia
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 63,833,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 322 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Behavioral - analgesia
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 63,833,1975

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BUCABS Bulletin du Cancer.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-
   1966-  Volume(issue)/page/year: 67,245,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,23,1978

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 umol/L
REFERENCE :
   BUCABS Bulletin du Cancer.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-
   1966-  Volume(issue)/page/year: 67,245,1980

其他信息

  • MOL 文件:523-50-2.mol
  • 上游原料:盐酸 --> 乙酸乙酯 --> 甲醇 --> 乙醚 --> 四氢呋喃 --> 石油醚 --> 硫酸镁 --> 氢氧化钾 --> 氯化钠 --> 碳酸氢钠 --> 苯 --> 氢化钠 --> 二甲苯 --> 甲酸乙酯 --> 氯乙醛 --> 1,3-环己二酮 --> 氢化钾 --> 2,3-二氯-5,6-二氰基-1,4-苯醌 --> 乙氧甲酰基亚甲基三苯基膦
  • Sigma Aldrich:523-50-2(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. AN-AZ - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. DNA metabolism - Apoptosis and Cell Cycle
  6. DNA Intercalators and Crosslinkers - DNA metabolism

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