(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-Yl)Nona-2,4,6,8-Tetraenoic Acid (2E,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基环己-1-烯-1-基)壬-2,4,6,8-四烯酸

CAS 5300-03-8 MFCD00270072

化学结构图

5300-03-8
SMILES: CC1=C(/C=C/C(C)=C\C=C\C(C)=C/C(=O)O)C(C)(C)CCC1

化学属性

Mol. FormulaC20H28O2
Mol. Weight300
Melting Point178-180°
TSCANo

别名和识别编码

Chemical Name(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-Yl)Nona-2,4,6,8-Tetraenoic Acid
CAS Number5300-03-8
Synonym LGD 100057 (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic Acid 9-cis-Tretinoin ALRT 1057 LG 100057 9-CIS-RETINOIC ACID 9-顺式维甲酸 Alitretinoin AGN 192013 9-顺式视黄酸 NSC 659772 LGD 1057 (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid 9-顺式维甲酸 Alitretinoin Panretin
MDL NumberMFCD00270072
PubChem Substance ID24899373
Merck Number14,249
Chemical Name Translation(2E,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基环己-1-烯-1-基)壬-2,4,6,8-四烯酸
LabNetwork Molecule IDLN00193790
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分类

  • Retinoids,
  • {SNA} Antitumor Agents, Bioactive Small Molecule Alphabetical Index,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation, Gene Regulation and Expression, Isoprenoids, PPAR and RXR Regulators, Prenols, R, Vitamin A, Vitamins, 抗肿瘤药物, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 脂类
  • {SNA} Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, Isoprenoids,

产品应用

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相关文献及参考

  • [2]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64.
  • [3]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194.
  • [4]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83.
  • [5]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5.
  • Heyman, R.A., et al.: Cell, 68, 397 (1992),
  • Levin, A.A., et al.: Nature, 355, 359 (1992),
  • [1]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P305+P351+P338
  • P308+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Danger
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
RTECSVH6450000
Storage condition -20°C Moisture & Light Sensitive

其他信息

  • MOL 文件:5300-03-8.mol
  • Sigma Aldrich:5300-03-8(sigmaaldrich)

系列性分类


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