二氯甲基醚 二氯甲基醚

CAS 542-88-1 MFCD00152275

化学结构图

542-88-1
SMILES: ClCOCCl

化学属性

Mol. FormulaC2H4Cl2O
Mol. Weight114.96
Solubility可混溶于乙醇、乙醚等多数有机溶剂。

别名和识别编码

Chemical NameEther, bis(chloromethyl)
CAS Number542-88-1
Synonym Chloro(chloromethoxy) methane α,α’-二氯甲醚 Oxybis[chloromethane] BCME 二氯(二)甲醚 氧代二氯甲烷 Monochloromethyl Ether Dichloromethyl ether Bis(chloromethyl)ether chloromethylether {Chemi Dimethyl-1,1'-dichloroether bis(chloromethyl) 对称二氯二甲醚 bis (chloromethyl) ether chloro(chloromethoxy)methane sym-Dichloro-dimethyl ether sym-Dichloromethyl ether Dichlorodimethyl ether, symmetrical Bis(chloromethyl) ether bis-chloromethyl Methane, oxybis[chloro- 双-(氯甲基)醚 Dichlordimethylaether Methane, oxybis(chloro- RCRA waste number P016 DICHLORO(ALPHA, ALPHA'-)METHYLMETHYL ETHER dichloromethylether,symmetrical BIS(CHLOROMETHYL)ETHER Dichlorodimethyl Ether Α,Α′-二氯甲醚 dimethyl-1,1’-dichloroether {h Bis(chlormethyl)ether alpha,alpha'-Dichlorodimethyl ether chloro-chloromethoxy-methane Bis-(chlormethyl)ether bis(chloromethyl) ether Monochloromethyl ether sym-Dichloromethyl ether α,α'-Dichlorodimethyl ether sym-Dichloromethyl E Chloro(chloromethoxy)methane Chloromethyl ether Oxybis(chloromethane) bis-chloromethyl ether Ether, bis(chloromethyl) dichlorodimethylether Bis-CME alpha,alpha’-dichlorodimethylether Dichlorodimethyl ether Dimethyl-1,1-dichlorether 二氯甲基醚 Bis (2-chloromethyl) ether dichlorodimethyle
Chemical Name Translation二氯甲基醚
Wiswesser Line NotationG1O1G
Beilstein Registry Number1679223
PubChem Substance ID10967
InChIInChI=1S/C2H4Cl2O/c3-1-5-2-4/h1-2H2
LabNetwork Molecule IDLN01279062
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分类

  • Miscellaneous Reagents
  • {uni_hamburg} no charge; 1fragment

产品应用

  • Reagent used in the formation of ether linked dimers

相关文献及参考

  • Short: II/25B Title: Structure Data Of Free Polyatomic Molecules: Molecules containing One or Two Carbon Atoms Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25B Year: 1999 Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules ISBN: 3-540-63645-5 ISBN: 978-3-540-63645-8 Internet Resource: DOI:10.1007/b68834 RefComment: IX, 512 pages. Hardcover Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure and the original literature.
  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20a Year: 1988 Keyword: NQR ISBN: 3-540-18161-X ISBN: 978-3-540-18161-3 Internet Resource: DOI:10.1007/b31153 RefComment: IX,677 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: III/38B Title: Refractive Indices of Organic Liquids Author: Wohlfarth, C

安全信息

Hazard Codes T+
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R10 Flammable 易燃
  • R26 Very toxic by inhalation 吸入极毒
  • R22 Harmful if swallowed 吞咽有害
  • R45 May cause cancer 可能致癌
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number 2249
Restrict {} 剧毒化学品 危险品
Warnings 危化品目录(2015) 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 ppb/6H/4W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,73,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 384 mg/kg/42W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,352,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5520 mg/kg/23W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   16,472,1968

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 ppb/6H/6W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Pr

RTECSKN1575000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 280 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   30,470,1969

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 100 ppm/3M
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TJSGA8 Tijdschrift Voor Sociale Geneeskunde.  (B.V. Uitgeversmaatschappij.
   Reflex, Mathenesserlaan 310, Rotterdam 3003, Netherlands)  V.1-    1923-
   Volume(issue)/page/year: 51,596,1973

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 ppm/7H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,61,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 7 ppm/7H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,61,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentra

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 160 ug/L
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 21,151,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 ug/plate
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 360 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,769,1973

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 360 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,769,1973

其他信息

  • 外观性质:无色液体，有刺激性气味。易挥发。
  • HazardClass:6.1(a)
  • PackingGroup:I
  • 生产方法:由多聚甲醛经氯化而得。
  • MOL 文件:542-88-1.mol
  • 用途:作药物消瘤芥、八氮二丙醚、双解磷的中间体。也是维生素B2的中间体（合成3,4-二甲基苯胺的原料）。

系列性分类

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