A-443654
CAS 552325-16-3 MFCD52325163
化学结构图
SMILES: Cc1[nH]nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12
化学属性
| Mol. Weight | 397.47 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | A-443654 |
|---|---|
| Formula | C24H23N5O |
| Synonym | A443564; A-443564; A 443564. |
| IUPAC Name | (S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine |
| InChIKey | YWTBGJGMTBHQTM-IBGZPJMESA-N |
| InChI | InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1 |
| Canonical SMILES | N[C@H](COC1=CC(C2=CC3=C(C)NN=C3C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5 |
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产品应用
- A-443654 is a potent and selective AKT inhibitor. A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. A-443654 interferes with mitotic progression by regulating aurora a kinase expression.
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