Trichostatin A 曲古抑菌素 A

CAS 58880-19-6 MFCD03848392

化学结构图

58880-19-6
SMILES: C/C(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)C1C=CC(=CC=1)N(C)C

化学属性

Mol. FormulaC17
Mol. Weight302

别名和识别编码

Chemical NameTrichostatin A
Synonym TSA TSA [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide Trichostatin A Trichostatin A, Ready Made Solution [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
CAS Number58880-19-6
Reaxys-RN2391788
PubChem Substance ID87560260
MDL NumberMFCD03848392
Merck Number9649
Chemical Name Translation曲古抑菌素 A
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分类

  • {SNA} Antitumor Agents, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, D to K, DNA-RNA Transcription Regulators, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epigenetics, Gene Regulation and Expression, Histone Deacetylase Inhibitors, Histone deacetylase, Hydroxamic Acid Inhibitors, Molecular Biology, Reagents, Small Molecules for Stem Cell Biology, Stem Cell Biology, T, Tools for Gene Regulation Research
  • {SNA} Antibiotic Ready Made Sol
  • {SNA} Antibiotic Ready Made Solutions,

相关文献及参考

  • [2]. Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.,Reprod Sci. 2012 Aug 8.
  • [3]. Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.,Stem Cells Dev. 2012 Aug 8.
  • [4]. Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47.
  • Brehm, A., et al., Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391 , 597-601, (1998) 摘要
  • Choi SJ, Park SY, Han TH, 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSMI5215000
Storage condition <;0 <0°C
Signal word
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302+H312+H332
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340+P312
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P302+P352+P312+P362+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P305+P351+P338+
GHS Symbol
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 177,122,1988

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 177,122,1988

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. DNA-RNA Transcription Regulators - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Epigenetics - Molecular Biology
  4. Bioactive Small Molecules for Epigenetic Research - Epigenetics
  5. Histone Deacetylase Inhibitors - Bioactive Small Molecules for Epigenetic Research
  6. Hydroxamic Acid Inhibitors - Histone Deacetylase Inhibitors
  1. Functional Group 官能团索引
  2. hydroxamic acid

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