Cis-4-Hydroxy-L-Proline 顺式-4-羟基-L-脯氨酸

CAS 618-27-9 MFCD00064319

化学结构图

618-27-9
SMILES: O=C(O)C1CC(O)CN1

化学属性

Mol. FormulaC5H9NO3
Mol. Weight131.13
Density1.422
Melting Point257°C
TSCAYes
Solubility可溶
Refractive index-59 ° (C=2, H2O)
Boiling Point355.2°C at 760 mmHg

别名和识别编码

Chemical NameCis-4-Hydroxy-L-Proline
CAS Number618-27-9
Synonym cis-4-Hydroxy-L-proline {LY} cis-4-Hydroxy-L-proline {} {LY} cis-4-Hydroxy-L-proline {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} cis-4-Hydroxy-L-proline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number210-542-1
Beilstein Registry Number81440
MDL NumberMFCD00064319
PubChem Substance ID440015
Chemical Name Translation顺式-4-羟基-L-脯氨酸
Reaxys-RN81440
Merck Number4840
LabNetwork Molecule IDLN00335236
InChIInChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
Canonical SMILESO=C(O)[C@H](C1)NC[C@H]1O
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分类

  • Amino Acids & Derivatives
  • {SNA} A - H, Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Modified Amino Acids, Peptide Chemistry, Proline Derivatives, Unnatural Amino Acid Derivatives
  • Chiral Reagents
  • Heterocycles
  • {SA} Chemical Biology, Chemical Synthesis, Peptide Chemistry, Proline Derivatives, Unnatural Amino Acid Derivatives
  • {SNA} A - H, Amino Acids, Chemical Biology, Chemical Synthesis, Modified Amino Acids, Peptide Chemistry, Proline Derivatives, Unnatural Amino Acid Derivatives, 生化试剂

产品应用

  • Amanita sp.多肽毒素的组成部分,但不像胶原蛋白那样,它不属于动物蛋白

相关文献及参考

  • [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.
  • [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.
  • [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.
  • Lawrence, C., et al.: Biochem. J., 313, 185 (1996),
  • Merck: 14,4840
  • Merck: 14,4840 Beilstein:22(5)5,7
  • [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.
  • [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.
  • [2]. Kao WW, e

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • Alfa Aesar:顺-4-羟基-L-脯氨酸,99% cis-4-Hydroxy-L-proline, 99%(618-27-9)
  • Acros Organics:顺-4-羟基-L-脯氨酸 cis-4-Hydroxy-L-proline, 99%(618-27-9)
  • TCI Shanghai:顺-4-羟基-L-脯氨酸 cis-4-Hydroxy-L-proline,>;97.0%(T)(618-27-9)
  • 溶于水,微溶于醇,不溶于醚。
  • MSDS 信息:cis-4-Hydroxy-L-proline(618-27-9).msds
  • F:10
  • 比旋光度:-59 ° (c=2, H2O)
  • 图谱信息:顺式-4-羟基-L-脯氨酸(618-27-9)红外图谱(IR2) 顺式-4-羟基-L-脯氨酸(618-27-9)红外图谱(IR1) 顺式-4-羟基-L-脯氨酸(618-27-9)核磁图( 13 CNMR) 顺式-4-羟基-L-脯氨酸(618-27-9)质谱(MS) 顺式-4-羟基-L-脯氨酸(618-27-9)核磁图( 1 HNMR)
  • MOL 文件:618-27-9.mol
  • 顺式-4-羟基-L-脯氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 SH163701 顺-4-羟基-L-脯氨酸 50mg 585元 2011/04/16 H1169 顺-4-羟基-L-脯氨酸 cis-4-Hydroxy-L-proline 100MG 663元 2011/04/16 H1169 顺-4-羟基-L-脯氨酸 cis-4-Hydroxy-L-proline 1G 3410元
  • Sigma Aldrich:618-27-9(sigmaaldrich)

系列性分类


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