Trans-L-Diaminocyclohexane Oxalatoplatinum 左旋反式二氨环己烷草酸铂

CAS 61825-94-3 MFCD00866327

化学结构图

61825-94-3
SMILES: N[C@@H]1CCCC[C@H]1N.O=C1O[Pt]OC1=O

化学属性

Mol. FormulaC8H14N2O4Pt
Mol. Weight397
Density1.422

别名和识别编码

Chemical NameTrans-L-Diaminocyclohexane Oxalatoplatinum
CAS Number61825-94-3
Alfabeta NameOXALIPLATIN
MDL NumberMFCD00866327
Synonym (反-1 Oxalato(1R,2R-cyclohexanediammine)platinum(II) [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N')[ethanedioata(2--)-O,O’]platinum (反-1,2-环己烷二胺)草酸铂(II) Oxalatoplatin 2-环己烷二胺)草酸铂(II) 1-OHP [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum ######## Oxaliplatino RP 54780 Oxaliplatin
EC Number250-023-7
Beilstein Registry Number14621501
Reaxys-RN14621501
PubChem Substance ID125309438
Merck Number6912
Chemical Name Translation左旋反式二氨环己烷草酸铂
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分类

  • {SNA} Antitumor Agents, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA Modification / Repair, DNA metabolism, O, Sanofi Aventis, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
  • Pharmaceuticals
  • Heterocycles
  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA Modification / Repair, DNA metabolism, O, Sanofi Aventis, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学,

产品应用

  • Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.

相关文献及参考

  • Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978),
  • Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993),
  • Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993),

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P304+P341
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P337+P313
  • P302+P352+P333+P313+P362+P364
  • P305+P351+
  • P308+P313
  • P302+P350
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSTP2275850
Signal word
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R42/43
Storage condition 0-10 储存温度 2-8°C 0-10°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   14,529,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   14,529,1989

其他信息

  • Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA.

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. O - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Sanofi Aventis - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. DNA metabolism - Apoptosis and Cell Cycle
  6. DNA Intercalators and Crosslinkers - DNA metabolism

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