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• {SNA} Adrenergics, Adrenergics - Antagonists, Alkaloid, Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Nutrition Research, Phytochemicals by Chemical Classification, Proteins and Derivatives, Y
• {SNA} Analytical Standards, EP Standards, EP Standards U - Z, Pharmacopeia Metrological Institutes Standards, 分析/色谱
• {SNA} Adrenergics, Adrenergics - Antagonists, Alkaloid,

产品应用

• α2-肾上腺索受体拮抗剂

相关文献及参考

• [2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4.
• [3]. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10.
• Merck: 14,10157 / Merck 14,10102
• Merck: 14,10157 / Merck 14,10102 Beilstein: 25,II,204
• [1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats.
• [1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats.
• [2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 133 ug/kg
TOXIC EFFECTS :
   Behavioral - euphoria
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 141,1267,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Autonomic Nervous System - central sympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 50,241,1935

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4179510

其他信息

• 图谱信息:盐酸育亨宾(65-19-0)红外图谱(IR1) 盐酸育亨宾(65-19-0)核磁图( 1 HNMR) 盐酸育亨宾(65-19-0)质谱(MS) 盐酸育亨宾(65-19-0)核磁图( 13 CNMR) 盐酸育亨宾(65-19-0)红外图谱(IR2)
• Sigma Aldrich:65-19-0(sigmaaldrich)
• 盐酸育亨宾价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 61005782 盐酸育亨宾 1g 609.7元 2011/08/23 61005780 盐酸育亨宾 5g 747.6元 2010/06/21 141030250 盐酸育亨宾 Yohimbine hydrochloride 99% 25 GR 3599元
• MOL 文件:65-19-0.mol
• 用途一:α2-肾上腺索受体拮抗剂
• 概述:盐酸育亨宾(分子结构式C21H26N2O3HCL，英文Yohimbine hydrochloride)又称萎必治、盐酸育亨宾、育亨宾碱、安慰乐得片、安慰乐得，外观为白色到乳白色精细粉末，气微香，味苦微涩，熔点288℃~290℃，易溶于氯仿，溶于甲醇、乙醇，微溶于水。植物来源野生于非洲植物育亨宾（Corynante Yohimbe）的干燥树皮或者西非植物茜草科柯楠树皮的提取物。药理功效表现为增加性肌张力，抑尿作用无损伤性； 加速肌体能量代谢，增加能量供给。临床单剂用于治疗男性各型阳痿及性功能减退。作用机理为能选择性地阻断突触前的α2受体，促进去甲肾上腺素的释放，使海绵体神经末梢释放较多的去甲肾上腺素，减少阴茎静脉回流，利于充血勃起，并能增加性液分泌。少量应用时，可使会阴部肿胀，刺激脊髓勃起中枢而使性功能亢进。
• color:white to off-white
• TCI Shanghai:盐酸育亨宾 Yohimbine Hydrochloride,>;99.0%(LC)(T)(65-19-0)
• MSDS 信息:Yohimbine hydrochloride(65-19-0).msds
• Acros Organics:育亨宾盐酸盐 Yohimbine hydrochloride, 99%(65-19-0)
• 比旋光度:99 ° (c=1%, H2O, dry subst)