• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Fatty Acids and conjugates,
• {SNA} AN-AZ, Arachidonic Acid, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
• {SNA} AN-AZ, Arachidonic Acid, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Fatty Acids and conjugates, Fatty Acyls, Functional Foods, Lipids, Lipids in Cell Signaling, Omega 6 fatty acids and derivatives, Polyunsaturated, Polyunsaturated Fatty Acids (PUFAs) and Omega-3 Fatty Acids, Unsaturated Fatty Acids and Derivatives, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 脂类, 营养研究

相关文献及参考

• Ghosh, J., and Myers, C.E., Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc. Natl. Acad. Sci. U. S. A. 95 , 13182-13187, (1998) 摘要
• Prigge, S.T., et al., Structure and mechanism of lipoxygenases. Biochimie 79 , 629-636, (1997)
• Karim, S., et al., Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J. Biol. Chem. 271 , 12042-12048, (1996)
• Krischer, S.M., et al., Transport of arachidonic acid across the neutrophil plasma membrane via a protein-facilitated mechanism. Biochemistry 37 , 12884-12891, (1998) 摘要
• Makita, K., et al., Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 10 , 1456-1463, (1996)
• Kim, B.C, and Kim, J.H.,, Nuclear signalling by Rac GTPase: essential role of phospholipase A2. Biochem. J. 326 , 333-337, (1997)
• Seegers, J.C., et al., Comparative anti-mitotic effects of lithium γ-linolenate, γ-linolenic acid and arachidonic acid, on transformed and embryonic cells. Prostaglandins Leukot. Essent. Fatty Acids 59 , 285-291, (1998) 摘要
• Williams, J.R., et al., Apoptosis in human primary brain tumours: actions of arachidonic acid. Prostaglandins Leukot. Essent. Fatty Acids 58 , 193-200, (1998)
• Hallak, H., et al., Covalent binding of arachidonate to G protein alpha subunits of human platelets. J. Biol. Chem. 269 , 4713-4716, (1994) 摘要
• Sermon, B.A., et al., Mechanism of inhibition by arachidonic acid of the catalytic activity of Ras GTPase-activating proteins. J. Biol. Chem. 271 , 1566-1572, (1996) 摘要

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 224,369,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory obstruction
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   THBRAA Thrombosis Research.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.1-    1972-  Volume(issue)/page/year: 9,67,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory obstruction
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   THBRAA Thrombosis Research.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.1-    1972-  Volume(issue)/page/year: 9,67,1976