L-Carnitine hydrochloride L-肉毒碱盐酸盐

CAS 6645-46-1 MFCD00066100

化学结构图

6645-46-1
SMILES: C[N+](C)(C)CC(O)CC(=O)[O-].Cl

化学属性

Mol. FormulaC7H16ClNO3
Mol. Weight197.66
Melting Point142°C
Appearance 本品为白色粉末,极易溶于水。
Solubilitysoluble

别名和识别编码

Chemical NameL-Carnitine hydrochloride
MDL NumberMFCD00066100
CAS Number6645-46-1
Synonym L-Carnitine (hydrochloride) {SNA} (-)-β-羟基-γ-(三甲铵)丁酸 维生素 BT (-)-β-羟基-γ-(三甲铵)丁酸, (R)-(3-carboxy-2-hydroxypropyl)trimethylammonium chloride (R)-(3-羧基-2-羟丙基)三甲铵基氢氧化物盐酸盐 (R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium Chloride {} {hazard_com} (-)-(3-Carboxy-2-hydroxypropyl)trimethylammonium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID656657
EC Number229-663-6
Chemical Name TranslationL-肉毒碱盐酸盐
Merck Number1849
Reaxys-RN4301819
Wiswesser Line NotationQV1YQ1K1&1&1 &G
LabNetwork Molecule IDLN00195905
Canonical SMILESC[N+](C)(C)C[C@H](O)CC(O)=O.[Cl-]
InChIInChI=1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1
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分类

  • {SNA} Amino Acid, Amino Acid Library Collection, Metabolite Libraries and Collections, Other Biochemical, Phytochemicals by Chemical Classification, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 细胞生物学, 营养研究
  • {SNA} Amino Acid, Amino Acid Library, Cell Biology, Metabolic Libraries, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart,
  • {SNA} Amino Acid, Amino Acid Library, Metabolic Libraries, Other Biochemical, Phytochemicals by Chemical Classification, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 细胞生物学, 营养研究

相关文献及参考

  • [2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.
  • [3]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.
  • [4]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.
  • [1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5.
  • [1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5.
  • [2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.
  • [3]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-16

安全信息

WGK Germany2
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSBP2979100
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, sealed storage, away from moisture {LY} -20℃ 2-8°C {} {Chemicalbook} -20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1920 mg/kg
TOXIC EFFECTS :
   Vascular - other changes
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,191,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,446,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2272 mg/kg
TOXIC EFFECTS :
   Vascular - other changes
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,238,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respirati

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 33 gm/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,465,1988

其他信息

  • 比旋光度:-22 ° (c=1, H2O)
  • 类别:有毒物质
  • 可燃性危险特性:热分解排出有毒氮氧化物, 氯化氢烟雾
  • 储运特性:库房低温通风干燥
  • 毒性分级:低毒
  • Acros Organics:L(-)-卡尼丁 L(-)-Carnitine hydrochloride, 99%(6645-46-1)
  • MSDS 信息:L(-)-Carnitine hydrochloride(6645-46-1).msds
  • Sigma Aldrich:6645-46-1(sigmaaldrich)
  • 灭火剂:水,二氧化碳, 泡沫, 干粉
  • MOL 文件:6645-46-1.mol
  • 急性毒性:口服-大鼠 LD50: 6890 毫克/公斤; 口服-小鼠 LD50: 8000 毫克/公斤
  • 肉毒碱是季铵，天然存在于大多数哺乳动物组织中。它在骨骼肌和心脏中参与能量代谢调控，浓度相对较高。它可将葡萄糖代谢由糖酵解转移至糖原储存，并促进长链脂肪酸向线粒体转运，使其在线粒体氧化产生能量。
  • 左旋肉碱盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 230280500 左旋肉碱盐酸盐 L(-)-Carnitine hydrochloride 99% 50 MG 780元 2010/06/21 230285000 左旋肉碱盐酸盐 L(-)-Carnitine hydrochloride 99% 500 MG 4934元

系列性分类

  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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