Furazolidone 呋喃唑酮
CAS 67-45-8 MFCD00010550
化学结构图
SMILES: O=C1OCCN1/N=C/c1ccc([N+](=O)[O-])o1
化学属性
| Mol. Formula | C8H7N3O5 |
|---|---|
| Mol. Weight | 225.16 |
| Melting Point | 254-256 |
| TSCA | Yes |
| Density | 1.66 |
别名和识别编码
| Chemical Name | Furazolidone |
|---|---|
| CAS Number | 67-45-8 |
| Synonym | 2-Oxazolidinone, 3-(((5-nitro-2-furanyl)methylene)amino)- 3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone 3-(5'-Nitrofurfuralamino)-2-oxazolidone 3-(5-Nitrofurfurylideneamino)- 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone 3-（5-硝基糠叉氨基）-2-唑烷酮 Furaxon Furazolidone {hazard_com} Furazon Furidon Furovag Furox Furoxane Furoxon Furoxone Furozolidine Giardil Giarlam Medaron N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one NF 180 custom mix ten NF-180 Neftin Nicolen Nifulidone Nifuran Nitrofurazolidone Nitrofurazolidonum Ortazol Puradin Roptazol Tikofuran To |
| MDL Number | MFCD00010550 |
| PubChem Substance ID | 24894997 |
| Beilstein Registry Number | 384794 |
| EC Number | 200-653-3 |
| Chemical Name Translation | 呋喃唑酮 |
| InChIKey | PLHJDBGFXBMTGZ-WEVVVXLNSA-N |
| Wiswesser Line Notation | T5OJ BNW E1UN- AT5NVOTJ |
| LabNetwork Molecule ID | LN00236153 |
| Canonical SMILES | O=C1OCCN1/N=C/C2=CC=C([N+]([O-])=O)O2 |
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资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} A - K,
- {SNA} A - K, Additional Standards, Analytical Standards, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Antibiotics Standards, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, Food and Cosmetic Component Standards, Inhibits an Enzyme, Mechanism of Action, Others, Pesticides, Bactericides, Fungicides and Disinfectants, Pharmaceuticals, Illicit Drugs & Alcohol, Principle, Spectrum of Activity, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱, 抗生素,
- {SNA} A - K,
产品应用
- 较广抗菌谱的杀菌剂。作为抗感染类药物，对多种革兰氏阳性及阴性的大肠杆菌，炭疽杆菌，副伤寒杆菌等有效。
相关文献及参考
- Merck: 14,4300
- Yurchenco, J.A., et al.: Antimicrob. Chemother., 3, 1035 (1953),
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST :
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 178 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 51,89,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,301,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2336 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 5,320,1967
TYPE OF TEST
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 30 ng/plate REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,256,1978
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ng/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherland
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 1 ug/disc REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 2 mg/L/72H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 59,139,1979
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 10 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,3,1974
TYPE OF TEST :
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 50 ug/L REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,1
TYPE
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 700 mg/kg SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : APJAAG Acta Pathologica Japonica. (Japan Publications Trading Co., Ltd., POB 5030, Tokyo International, Tokyo 101-31, Japan) V.1- 1951- Volume(issue)/page/year: 14,261,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 250 mg/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 14,284,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 840 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 53,585,1953
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 1 gm/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproducti
其他信息
- 溶于氯仿、水、乙醇和四氯化碳，11g水中溶40mg该品。稍溶于二甲基甲酰胺。无臭、味苦。
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