(±)-Norverapamil hydrochloride

CAS 67812-42-4 MFCD00078605

化学结构图

67812-42-4
SMILES: [2H]C(C(CCCNCCC1C=CC(OC)=C(C=1)OC)(C#N)C1C=C(OC)C(=CC=1)OC)(C([2H])([2H])[2H])C([2H])([2H])[2H]

化学属性

Mol. FormulaC26H36N2O4· HCl
Mol. Weight477.04

别名和识别编码

Chemical Name(±)-Norverapamil hydrochloride
Synonym (±)-Norverapamil hydrochloride N-Nor-(±)-verapamil hydrochloride
MDL NumberMFCD00078605
PubChem Substance ID24900707
Chemical Name Translation
CAS Number67812-42-4
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分类

  • {SNA} Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, N, Verapamil, Voltage-gated Ion Channels
  • {SNA} Bioactive Small Molecule Alphabetical Index, Calcium Channel Modulators, Ion Channels, N, Verapamil,

相关文献及参考

  • [2]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.
  • [3]. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.
  • [4]. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8.
  • [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-me
  • [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
Precautionary statements
  • P301+P312+P330
  • P305+P351+P338
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Calcium Channel Modulators - Voltage-gated Ion Channels
  7. Verapamil - Calcium Channel Modulators
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Calcium Channel Modulators - Voltage-gated Ion Channels
  7. Verapamil - Calcium Channel Modulators
  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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