T863 反式-4-(4-(4-氨基-7,7-二甲基-7H-嘧啶并(4,5-b)(1,4)恶嗪-6-基)苯基)环己烷乙酸
CAS 701232-20-4 MFCD11977270
化学结构图
SMILES: CC1(C)OC2N=CN=C(N)C=2N=C1C1=CC=C(C=C1)[C@@H]1CC[C@@H](CC(O)=O)CC1 |&1:19,22|
化学属性
| Mol. Formula | C22H26N4O3 |
|---|---|
| Mol. Weight | 394.47 |
别名和识别编码
| Chemical Name | T863 |
|---|---|
| Synonym | 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid T-863 trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid T863 |
| MDL Number | MFCD11977270 |
| Chemical Name Translation | 反式-4-(4-(4-氨基-7,7-二甲基-7H-嘧啶并(4,5-b)(1,4)恶嗪-6-基)苯基)环己烷乙酸 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism, Lipids in Cell Signaling, New Products
- {SNA} Bioactive Small Molecule Alphabetical Index, Cholesterol and Cholesterol Metabolism, Lipids in Cell Signaling, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.
- [3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46.
- [1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
- [1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
- [2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine
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