Phosmet 亚胺硫磷
CAS 732-11-6 MFCD00055501
化学结构图
SMILES: COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O
化学属性
| Mol. Formula | C11H12NO4PS2 |
|---|---|
| Mol. Weight | 317 |
| Melting Point | 71.9°C |
| Flash Point | >100 °C |
| Solubility | 微溶于水，溶于多数有机溶剂。 |
| Density | 0.791 |
别名和识别编码
| Chemical Name | Phosmet |
|---|---|
| Synonym | (O,O-Dimethyl-phthalimidiomethyl-dithiophosphate) 0，0-二甲基-S-(酞酰亚胺甲基)二硫 Decemthion Decemthion P-6 Dithiophosphorsäure-O,O-dimethyl-S-phthalimidomethylester ENT 25,705 Fosmet Ftalophos IMIDITHION Imidan Imidan; Phosphorodithioic acid S-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl] O,O-dimethyl ester N-(Mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorothionate) N-(dimethoxyphosphinothioylthiomethyl)phatalimid N-(mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorodithioate) N-(mercaptomethyl)phthalimide S-(O,O-dimethylphosphorodithioate) O,O dimethyl phthalimidomethyl phosphorodithioat O,O-DIMETHYL PHTHALIMIDO-METHYL-PHOSPHOROTHIOLOTHIONATE O,O-Dimethyl 5-(phthalimidomethyl)dithiophosphate O,O-Dimethyl S-phtha |
| CAS Number | 732-11-6 |
| EC Number | 211-987-4 |
| Beilstein Registry Number | 0264869 |
| MDL Number | MFCD00055501 |
| Chemical Name Translation | 亚胺硫磷 |
| Wiswesser Line Notation | T56 BVNVJ C1SPS&O1&O1 |
| PubChem Substance ID | 12901 |
| InChI | InChI=1S/C11H12NO4PS2/c1-15-17(18,16-2)19-7-12-10(13)8-5-3-4-6-9(8)11(12)14/h3-6H,7H2,1-2H3 |
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分类
- {SNA} Acaricides,
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
- {SNA} Acaricides, Additional Standards, Analytical St
- {SNA} Additional Standards, Analytical Standards, EPA, Endocrine Disruptors (Draft), Insecticides, Method and Regulation Specific,
- Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, EPA, Endocrine Disruptors (Draft), Environmental Standards, H-M, I, Insecticides, Method Specific, Organophorous, Pesticides, Pesticides & Metabolites, Phthalimides
- {SNA} Additional Standards,
产品应用
- 该品是有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫。
相关文献及参考
- Merck: 14,7336
- Short: EINECS
- Short: IV/8A
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H302 Harmful if swallowed 吞食有害
- H302+H312
- H312 Harmful in contact with skin 皮肤接触有害
- H330 Fatal if inhaled 吸入致命
- H332 Harmful if inhaled 吸入有害
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H370 Causes damage to organs 导致器官损伤
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P203
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P301+P312
- P301+P316
- P301+P317
- P302+P317
- P302+P352
- P304+P312
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P307+P311
- P308+P313
- P308+P316
- P309+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P316
- P317
- P318
- P319
- P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
- R50/53
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1326 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,59,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >3160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A325,1983
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 74-1,-,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 132 mg/kg TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 35(12),94,19
TYPE OF TEST : LD50
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 25000 ppm REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 302,153,1993
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 1 pph REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 302,153,1993
TYPE OF TEST : DNA damage TEST SYSTEM : Human Fibroblast DOSE/DURATION : 63466 ug/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 20,73,1992
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 7933 ug/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- V
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 500 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 302,153,1993
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 20 mg/kg REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 11,1534,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 49600 ug/kg SEX/DURATION : female 1-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952- Volume(issue)/page/year: 34,791,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 124 mg/kg SEX/DURATION : female 1-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952- Volume(issue)/page/year: 34,791,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 6 mg/kg SEX/DURATION : female 1-20 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 56(1),62,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 6200 ug/kg SEX/DURATION : female 12 day(
其他信息
- 灭火剂:砂土、干粉、泡沫
- 用途二:广谱性有机磷杀虫剂，具有触杀和胃毒作用，对植物组织有一定的渗透性。用于水稻、棉花、果树等作物。可防治棉铃虫、棉红蜘蛛、红铃虫、稻叶蝉、稻飞虱、稻纵卷叶螟，用25%乳油22.5～30mL/100m 2 ,对水7.5～11.3kg喷雾。防治棉蚜、菜蚜，用25%乳油7.5～15mL/100m 2 ，对水7.5～11.3kg喷雾。防治苹果叶螨、柑橘介壳虫，用25%乳油600～1000倍液喷雾。防治地老虎，在幼虫3龄期进行防治，用25%乳油加水稀释至250倍烧根。
- 用途一:属有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫
- 急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g 静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
- 类别:农药
- 中毒症状:急性中毒多在12小时内发病，口服立即发病。轻度：头痛、头昏、恶心、呕吐、多汗、无力、胸闷、视力模糊、胃口不佳等，全血胆碱酯酶活力一般降 至正常值的70－50%。中度：除上述症状外还出现轻度呼吸困难、肌肉震颤 、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出现昏迷、抽搐、呼吸困难、口吐白沫、大小便失禁，惊厥，呼吸麻痹。
- 图谱信息:亚胺硫磷(732-11-6)红外图谱(IR2) 亚胺硫磷(732-11-6)红外图谱(IR1) 亚胺硫磷(732-11
- 毒性分级:剧毒
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- 用途三:该品是有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫。
- 方法一:邻苯二甲酰亚胺的制备 苯酐与碳酸氢铵作用制得邻苯二甲酰亚胺（简称亚酰胺）。配比为苯酐：碳酸氢铵=1：1.5 （mol)；反应温度280～300℃；操作周期6h。 N-羟甲基苯二甲酰亚胺的制备 亚酰胺与甲醛作用制得N-羟甲基苯二甲酰亚胺（简称羟化物）。原料配比为亚酰胺：甲苯=1：1.1，反应温度98～100℃，升温时间1.5h，反应时间3h，操作周期6～7h。 氯化甲基苯甲酰亚胺的制备 羟化物与盐酸作用制得氯代甲基苯甲酰亚胺（简称氯化物）。原料比为羟化物：盐酸≈1：6.6，升温时间40～50min，反应温度（60±2）℃。加苯温度55～58℃，盐酸含量35%，操作周期6h。 O,O-二甲苯硫代磷酸诼钠盐制备 详见乐果的制备方法。 亚胺硫磷的合成 O，O-二甲基硫代磷酸钠与氯代甲基苯甲酰亚胺作用，制得亚胺硫磷
- 上游原料:苄基氯 --> 碳酸氢铵 --> 五硫化二磷 --> 二甲基硫 --> 甲醛水溶液 --> 氯化物 --> 邻苯二甲酰亚胺 --> 乐果 --> 邻苯二甲酸 --> 二甲基二硫代磷酸酯 --> 硫代磷酸钠
- 毒性:大鼠急性经口LD 50 为147mg/kg（原药为230～299mg/kg)，鼷鼠急性经口LD 50 为34mg/kg，小鼠急性经口LD 50 为45mg/kg。兔急性经皮LD 50 >3160ng/kg，小鼠急性经皮LD 50 >1000mg/kg。大鼠及狗慢性无作用剂量为40mg/kg。对鱼类中等毒性，鲤鱼LC 50 为5.3mg/L。对蜜蜂LD 50 为18.1μg/只。
- 方法二:由O,O-二甲基二硫代磷酸酯与氯甲基苯二甲酰亚胺反应制得。中间体氯甲基苯二甲酰亚胺的制法：将邻苯二甲酸与20%氨水缓慢加热，温度上升至110-120℃时有大量水分蒸发。反应物用热水处理，得白色结晶邻苯二甲酰亚胺，将其与12%甲醛水溶液加热回流反应2.5h，冷却、过滤、水洗、干燥，得羟甲基苯二甲酰亚胺，而后用30-36%盐酸在甲苯中氯化，在60℃保温2h，得氯甲基苯二甲酰亚胺。原料消耗定额：苯酐（99%）700kg/t、氨水（25%）420kg/t、甲醇（99.5%）350kg/t、甲醛（30%）500kg/t、盐酸（36%）1230kg/t、碳酸氢钠370kg/t、五硫化二磷560kg/t、苯200kg/t。
- 产品特性:低毒广谱二硫代磷酸酯类杀虫杀螨剂。对高等动物毒性较低，对鱼类毒性中等，对蜜蜂有毒。
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