阿苯达唑砜 阿苯达唑砜

CAS 75184-71-3 MFCD00600775

化学结构图

75184-71-3
SMILES: CCCS(=O)(=O)C1C=CC2NC(NC(=O)OC)=NC=2C=1

化学属性

Mol. FormulaC12H15N3O4S
Mol. Weight297
Melting Point290-292
TSCANo

别名和识别编码

Chemical Name2-Benzimidazolecarbamic acid, 5-(propylsulfonyl)-,methyl ester
CAS Number75184-71-3
Synonym Methyl [5-​(propylsulfonyl)​-​1H-​benzimidazol-​2-​yl]​carbamate N-[6-(Propylsulfonyl)-1H-benzimidazol-2-yl]carbamic Acid Methyl Ester 5-(Propylsulfonyl)-2-benzimidazolecarbamic acid methyl ester Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate Carbamic acid, (5-(propylsulfonyl)-1H-benzimidazol-2-yl)-, methyl ester
MDL NumberMFCD00600775
Chemical Name Translation阿苯达唑砜
Wiswesser Line NotationT56 BM DNJ CMVO1 GSW3
Beilstein Registry Number8394880
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分类

  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A metabolite of Albendazole, an anthelmintic.

相关文献及参考

  • [2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.
  • Dominguez, L., et al.: Farmaco, 50, 697 (1995),
  • [1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.
  • [1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.
  • [2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

安全信息

RTECSDD6520700
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARCVBP Annales Recherches Veterinaires.  (Institut National de la Recherche
   Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles,
   France)  V.1-    1970-  Volume(issue)/page/year: 12,159,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ARCVBP Annales Recherches Veterinaires.  (Institut National de la Recherche
   Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles,
   France)  V.1-    1970-  Volume(issue)/page/year: 12,159,1981

GHS Symbol
Signal word
WGK Germany3
Precautionary statements

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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