7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one 7-氯-5-(2-氯苯基)-1,5-二氢苯并[e][1,4]硫氮杂卓-2(3H)-酮

CAS 75450-34-9 MFCD09055422

化学结构图

75450-34-9
SMILES: O=C1CSC(C2=CC(Cl)=CC=C2N1)C1C=CC=CC=1Cl

化学属性

Mol. FormulaC15H11Cl2NOS
Mol. Weight324.22

别名和识别编码

Chemical Name7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Synonym 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
MDL NumberMFCD09055422
PubChem Substance ID329775189
Chemical Name Translation7-氯-5-(2-氯苯基)-1,5-二氢苯并[e][1,4]硫氮杂卓-2(3H)-酮
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Voltage-gated Ion Channels

相关文献及参考

  • 1. Neumann, J.T., et al., CGP-37157 inhibits the sarcoplasmic reticulum Ca 2+ ATPase and activates ryanodine receptor channels in striated muscle Mol. Pharmacol. 79 , 141-147, (2011)
  • Neumann, J.T., et al., CGP-37157 inhibits the sarcoplasmic reticulum Ca 2+ ATPase and activates ryanodine receptor channels in striated Mol. Pharmacol. 79 , 141-147, (2011) 摘要
  • Palty, R., et al., NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc. Natl. Acad. Sci. U. S. A. 107 , 436-441, (2010) 摘要
  • Chalmers, S., and McCarron, J.G., Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors. Cell Calcium 46 , 107-113, (2009) 摘要
  • Czyz, A., and Kiedrowski, L., Inhibition of plasmalemmal Na+/Ca2+ exhange by mitochondrial Na+/Ca2+ exhange inhibitor 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP-37157) in cerebellar granule cells. Biochem. Pharmacol. 66 , 2409-2411, (2003)

安全信息

GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes Xn,N
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Ion Pump Inhibitors - Monovalent Ion Channels

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