4-Methyl-1H-pyrazole 4-甲基吡唑

CAS 7554-65-6 MFCD00005245

化学结构图

7554-65-6
SMILES: Cc1cn[nH]c1

化学属性

Mol. FormulaC4H6N2
Mol. Weight82.10
Refractive indexn20/D 1.495(lit.)
Boiling Point99-100 °C at 6 mmHg
Density0.993
Flash Point96°(204°F)
TSCANo
Melting Point13°C
Solubility可溶

别名和识别编码

Chemical Name4-Methyl-1H-pyrazole
CAS Number7554-65-6
Alfabeta NameMETHYLPYRAZOLE H41---
MDL NumberMFCD00005245
Synonym Fomepizole {LY} Fomepizole {} {LY} Fomepizole {} {} {LY} Fomepizole {} {} {} {LY} Fomepizole {} {} {} {} {LY} Fomepizole {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID3406
EC Number231-445-0
Beilstein Registry Number105204
Reaxys-RN105204
Merck Number4226
Chemical Name Translation4-甲基吡唑
Wiswesser Line NotationT5MNJ D1
LabNetwork Molecule IDLN00008830
InChIInChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
Canonical SMILESCC1=CNN=C1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 5ring; 1fragment
  • {SNA} Bioactive Small Molecules, Building Blocks, C3 to C5, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Building Blocks, C3 to C5, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles, 生物活性小分子, 细胞生物学
  • {SNA} Bioactive Small Molecules, Building Blocks, C3 to C5, Cell Biology, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles
  • {SNA} Building Blocks,
  • {SNA} Bui

相关文献及参考

  • [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10.
  • [3]. Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1.
  • [4]. https://www.tandfonline.com/doi/full/10.1080/24734306.2019.1705596
  • Li, T.-K., and Theorell, H. Acta Chem. Scand. 23 , 892, (1969)
  • Short: EINECS
  • Short: III/38B
  • Short: IV/18B
  • [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.
  • [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.
  • [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. An

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUQ7350000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P330+P331
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupIII
Hazard Class6.1(b)
UN Number 2810 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 534 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

其他信息

  • Sigma Aldrich:7554-65-6(sigmaaldrich)
  • MSDS 信息:Fomepizol(7554-65-6).msds
  • 检测方法:GC
  • F:10-23
  • TCI Shanghai:4-甲基吡唑 4-Methylpyrazole,>;98.0%(GC)(7554-65-6)
  • MOL 文件:7554-65-6.mol
  • 敏感性:Hygroscopic
  • 4-甲基吡唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0774 4-甲基吡唑 4-Methylpyrazole 1G 906元 2010/06/21 206970050 4-甲基吡唑 4-Methylpyrazole 97% 5 GR 3204元 2010/06/21 206970010 4-甲基吡唑 4-Methylpyrazole 97% 1 GR 777元
  • Acros Organics:4-甲基吡唑 4-Methylpyrazole, 97%(7554-65-6)
  • Alfa Aesar:4-甲基吡唑,97+% 4-Methyl-1H-pyrazole, 97+%(7554-65-6)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazines 吡嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazoles 吡唑
  5. C3 to C5 - Pyrazoles
  1. Analytical & Chromatography 分析化学与色谱
  2. Syringes
  3. GC Manual Syringes - Syringes
  4. Liquid sampling - GC Manual Syringes
  5. Standard syringe, 5-500 µL - Liquid sampling
  6. Hamilton Microliter™ Syringes, 700 Series - Standard syringe, 5-500 µL
  7. 700 Series, RN (Removable Needle) - Hamilton Microliter™ Syringes, 700 Series
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazoles 吡唑
  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)

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