(R)-(-)-Α-Methylhistamine (Dihydrochloride) (R)-1-(1H-咪唑-4-基)丙-2-胺二盐酸盐

CAS 75614-89-0 MFCD00083176

化学结构图

75614-89-0
SMILES: Cl.Cl.C[C@@H](N)CC1=CNC=N1

化学属性

Mol. FormulaC6H11N3· 2HCl
Mol. Weight198.09

别名和识别编码

Chemical Name(R)-(-)-Α-Methylhistamine (Dihydrochloride)
Synonym (R)(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride (R)(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride (R)(-)-α-Methylhistamine dihydrochloride
CAS Number75614-89-0
PubChem Substance ID24277778
MDL NumberMFCD00083176
Chemical Name Translation(R)-1-(1H-咪唑-4-基)丙-2-胺二盐酸盐
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分类

  • {SNA} Agonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, M, Membrane Protein Biology
  • {SNA} Agonists, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, M, Membrane Protein Biology Tools, Mistaminergics - Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细

相关文献及参考

  • Oishi, et al., Effects of the histamine H 3 -agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J. Neurochem. 52 , 1388, (1989) 摘要
  • Arrang, J. M., et al., Highly potent and selective ligands for histamine H 3 -receptors. Nature 327 , 117, (1987) 摘要
  • Gerhard, et al., Structure-activity relations of histamine analogs. XX. Absolute configuration and histamine-like activity of enantiomeric α-methyl histamines. Arch. Pharm. Res. 313 , 709, (1980)

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Histaminergics - Neurotransmitters
  8. Agonists - Histaminergics

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