4-Bromo-calcium Ionophore A23187

CAS 76455-48-6 MFCD00077667

化学结构图

76455-48-6
SMILES: CNC1C(Br)=CC2OC(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC=2C=1C(O)=O

化学属性

Mol. FormulaC29H36BrN3O6
Mol. Weight602.52

别名和识别编码

Chemical Name4-Bromo-calcium Ionophore A23187
Synonym 4-Bromo-A23187 4-Bromo-calcimycin 4-Bromo-calcium Ionophore A23187
MDL NumberMFCD00077667
PubChem Substance ID24891982
CAS Number76455-48-6
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分类

  • Calcium Ionophores, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Signaling
  • {SA} Calcium Ionophores, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Signaling
  • {SNA} Antibiotics A to Z, Antibiotics A-F, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, 抗生素, 生化试剂
  • {SNA} Calcium Ionophores, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Signaling
  • {SNA} Calcium Ionophores, Calcium Signaling Research Tools, Intracellular Calcium Signaling, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • Wang, E., et al., Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin. Biophys. J. 75 , 1244-1254, (1998) 摘要
  • Deber, C.M., et al., Bromo-A23187: a nonfluorescent calcium ionophore for use with fluorescent probes Anal. Biochem. 146 , 349-352, (1985)

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Calcium Signaling Research Tools - Intracellular Calcium Signaling
  6. Calcium Ionophores - Calcium Signaling Research Tools

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