4-Nitrophenyl carbonochloridate 4-硝基苯基氯甲酸酯

CAS 7693-46-1 MFCD00007321

化学结构图

7693-46-1
SMILES: O=C(Cl)Oc1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC7H4ClNO4
Mol. Weight201.56
Density1.422
Boiling Point159-162°C at 760 mmHg
Melting Point77-79°C
Flash Point>110°(230°F)
TSCAYes
Solubility分解
Appearance isopropanol suspension

别名和识别编码

Chemical Name4-Nitrophenyl carbonochloridate
MDL NumberMFCD00007321
CAS Number7693-46-1
EC Number231-706-9
Beilstein Registry Number6(1)120
Synonym 4-Nitrophenyl chloroformate {LY} 4-Nitrophenyl chloroformate {} {LY} 4-Nitrophenyl chloroformate {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrophenyl chloroformate {} {} {} {} {} {} {} {}
PubChem Substance ID82129
Reaxys-RN518127
Chemical Name Translation4-硝基苯基氯甲酸酯
InChIKeyNXLNNXIXOYSCMB-UHFFFAOYSA-N
LabNetwork Molecule IDLN00196444
InChIInChI=1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
Canonical SMILESO=C(Cl)OC1=CC=C([N+]([O-])=O)C=C1
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分类

  • {SNA} Active Esters/Additives, Chemical Synthesis, Coupling, Synthetic Reagents
  • {SNA} Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents

相关文献及参考

  • Reagent for protection of nucleoside alcohols. The carbonate derivatives readily undergo aqueous hydrolysis in the presence of imidazole: J. Org. Chem., 33, 3699 (1967). For use in the formation of a carbonate linker in an efficient N-terminal attachment methodology for solid phase peptide synthesis, see: Synlett, 1609 (2000).

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
  • R34 Causes burns 会导致灼伤
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353+P310+P363
  • P304+P340+P311
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P303+P361+P353
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P304+P340+P310
  • P403+P233
  • P305+P351+P338+P310
  • P301+P330+P331+P310
Hazard statements
  • H301+H311+H331
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupII
UN Number 2923
Storage condition -20°C {LY} -20°C 0-10 0-10°C 2-8°C Moisture Sensitive {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes C
Hazard Class8/6.1

其他信息

  • 海关编码:29159020
  • Hazard Note:Toxic/Corrosive/Lachrymator
  • MSDS 信息:4-Nitrophenyl chloroformate(7693-46-1).msds
  • TCI Shanghai:4-硝基苯基氯甲酸酯 4-Nitrophenyl Chloroformate,>;98.0%(T)(7693-46-1)
  • MOL 文件:7693-46-1.mol
  • 存储注意事项:湿度敏感
  • 图谱信息:对硝基苯基氯甲酸酯(7693-46-1)红外图谱(IR2) 对硝基苯基氯甲酸酯(7693-46-1)红外图谱(IR1) 对硝基苯基氯甲酸酯(7693-46-1)质谱(MS)
  • Alfa Aesar:对硝基苯基氯甲酸酯,97% 4-Nitrophenyl chloroformate, 97%(7693-46-1)
  • F:19-21
  • Acros Organics:氯甲酸对硝基苯酯 4-Nitrophenyl chloroformate, 97%(7693-46-1)
  • 检测方法:GC,NMR
  • Sigma Aldrich:7693-46-1(sigmaaldrich)
  • 用途一:核苷类的羟基及氨基保护试剂，有机合成、医药合成中间体，可用于合成利托那韦（治疗艾滋病药物，蛋白酶抑制剂）。
  • 对硝基苯基氯甲酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1400 氯甲酸4-硝基苯酯 4-Nitrophenyl Chloroformate 250G 4490元 2014/06/02 C1400 氯甲酸4-硝基苯酯 4-Nitrophenyl Chloroformate 25G 723元 2010/06/21 170805000 对硝基苯基氯甲酸酯 4-Nitrophenyl chloroformate 97% 500 GR 12477元
  • 敏感性:Lachrymatory

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Active Esters/Additives - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Active Esters/Additives - Peptide Coupling
  1. Functional Group 官能团索引
  2. CO2 derivative (general)
  1. carbonic acid ester halide (alkyl/aryl haloformate)

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