Rifaximin 利福西亚胺
CAS 80621-81-4 MFCD00864973
化学结构图
SMILES: CO[C@H]1C=CO[C@@]2(C)OC3=C(C4C5N=C6C=C(C)C=CN6C=5C(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C(O)C=4C(O)=C3C)C2=O |c:18,29,56,t:3,15,31|
化学属性
| Mol. Formula | C43H51N3O11 |
|---|---|
| Mol. Weight | 786 |
| Melting Point | 210.0 to 214.0 deg-C |
别名和识别编码
| Chemical Name | Rifaximin |
|---|---|
| CAS Number | 80621-81-4 |
| Synonym | Rifacol L 105 (Ansamacrolide antibiotic) 利福西亚胺 Normix Xifaxan Rifamycin L 105 4-Deoxy-4?-methylpyridol[1?,2?-1,2]imidazo[5,4-c]rifamycin SV 4-脱氧-4′-甲基吡啶并[1′,2′-1,2]咪唑并[5,4-c]利福霉素 SV 利福昔明 Fatroximin Ritacol Rifaximin L 105 L-105 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV L 105SV Rifamycin L 105SV Rifaxidin |
| MDL Number | MFCD00864973 |
| PubChem Substance ID | 172089119 |
| Chemical Name Translation | 利福西亚胺 |
| Reaxys-RN | 3584528 |
| Merck Number | 8220 |
| Beilstein Registry Number | 3584528 |
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分类
- {SNA} Analytical Standards, Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics Standards, Chemical Structure Class, L - Z, Macrolides, Pharmaceuticals, Illicit Drugs & Alcohol, Spectrum of Activity, 分析/色谱, 抗生素, 生化试剂
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Chemical Structure Class, Interferes with Protein Synthesis, L - Z, Macrolides, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- Chiral Reagents
- Pharmaceuticals
- {SNA} Alphabetical Index of Analytical Standards, Analytic
- Intermediates & Fine Chemicals,
产品应用
- Non-absorbable semisynthetic Rifamycin antibiotic.
相关文献及参考
- Brufani, M., et al.: J. Antibiot., 37, 1611 (1984),
- Gillis, J.C., et al.: Drugs, 49, 467 (1995),
- Huang, D.B., et al.: J. Infection, 50, 97 (2005),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,260,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHEMEV Chemioterapia. (Tipografia "Il Sedicesimo", Via Manneli 29r, 50136 Florence, Italy) V.1-7, 1982-88. Volume(issue)/page/year: 5,263,1986
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