RO-3306 2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮

CAS 872573-93-8 MFCD72573938

化学结构图

872573-93-8
SMILES: O=C1N=C(NCc2cccs2)S/C1=C/c1ccc2ncccc2c1

化学属性

Mol. Weight351.44
Appearance Solid powder
SolubilitySoluble in DMSO, not soluble in water.

别名和识别编码

Chemical Name Translation2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮
Chemical NameRO-3306
FormulaC18H13N3OS2
Synonym RO3306; RO 3306; RO-3306
IUPAC Name5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
InChIKeyXOLMRFUGOINFDQ-MHWRWJLKSA-N
InChIInChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+
Canonical SMILESO=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Bcl-2
  1. Medical Research Areas
  2. Apoptosis
  3. Mdm2

相关产品推荐