15-deoxy-.delta.12,14-Prostaglandin J2 Lipid Maps MS Standard

CAS 87893-55-8 MFCD00065806

化学结构图

87893-55-8
SMILES: CCCCC/C=C/C=C1\[C@@H](C/C=C\CCCC(O)=O)C=CC\1=O

化学属性

Mol. FormulaC20H28O3
Mol. Weight316.43

别名和识别编码

Chemical Name15-Deoxy-Δ12,14-prostaglandin J2
Synonym 11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid 11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid 15-Deoxy-Δ12,14-PGJ2 15-Deoxy-Δ12,14-PGJ2
CAS Number87893-55-8
EC Number201-185-2
MDL NumberMFCD00065806
PubChem Substance ID329798863
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分类

  • {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, D-DIF, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Gene Regulation, Lipids in Cell Signaling, Prostaglandins, 抗肿瘤药物, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 脂类
  • {SN
  • Antitumor Agents, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, D-DIF, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Gen

相关文献及参考

  • [2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.
  • Han, C., et al., PPARγ ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Hepatology 38 , 167-177, (2003) 摘要
  • Leung, W.K., et al., Effect of peroxisome proliferator activated receptor-γ ligands on growth and gene expression profiles of gastric cancer cells. Gut 53 , 331-338, (2004) 摘要
  • Na, H.K., and Surh, Y.J., Peroxisome proliferator-activated receptor-γ (PPARγ) ligands as bifunctional regulators of cell proliferation. Biochem. Pharmacol. 66 , 1381-1391, (2003)
  • Paumi, C.M., et al., Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Δ 12,14 -prostaglandin J 2 in MCF7 breast cancer cells. Biochemistry 42 , 5429-5

安全信息

GHS Symbol
WGK Germany2
Hazard Codes F,Xi
Hazard statements
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P304+P340+P312
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P337+P313
  • P403+P235
Signal word Danger
Risk Statements
  • R11 Highly flammable 非常易燃
  • R36 Irritating to eyes 刺激眼睛
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Safety Statements
  • S33 Take precautionary measures against static discharges 对静电采取预防措施；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S29 Do not empty into drains 不要排入下水道；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Antitumor Agents - Cancer Research
  4. Gene Regulation - Antitumor Agents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Eicosanoids (Prostaglandins, Leukotrienes) - Fatty Acyls
  6. Prostaglandins - Eicosanoids (Prostaglandins, Leukotrienes)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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