LY171883
CAS 88107-10-2 MFCD00211057
化学结构图
SMILES: CC(=O)C1C=CC(OCCCCC2NN=NN=2)=C(CCC)C=1O
化学属性
| Mol. Formula | C16H22N4O3 |
|---|---|
| Mol. Weight | 318.37 |
别名和识别编码
| Chemical Name | LY-171,883 |
|---|---|
| Synonym | 1-(2-Hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)phenyl)ethanone 5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole 5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole Tomelukast Acetophenone, 2'-hydroxy-3'-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)- LY-171,883 LY171883 Tomelukast |
| MDL Number | MFCD00211057 |
| PubChem Substance ID | 24896403 |
| CAS Number | 88107-10-2 |
| Beilstein Registry Number | 4238438 |
| Chemical Name Translation |
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分类
- Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Leukotrienes, Lipids in Cell Signaling
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Leukotrienes, Lipids in Cell Signaling
- {SNA} Arachidonic Acid Cascade, Leukotrienes, Lipids in Cell Signaling, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- Fleisch, J.H., et al. J. Pharmacol. Exp. Ther. 233 , 148, (1985) 摘要
- Yamakawa, K., et al., Peroxisome proliferator-activated receptor-γ agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 271 , 571, (2000) 摘要
- Scholz-Pedretti, K. et al., Potentiation of TNF-α-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor-α activators in rat mesangial cells. J. Am. Soc. Nephrol. 13 , 611, (2002) 摘要
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Liver - other changes REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,672,1988
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,123,1990
TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 1260 mg/kg/1W (Continuous) REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991
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