Streptokinase from β-hemolytic Streptococcus (Lancefield Group C) Streptokinase

CAS 9002-01-1 MFCD00082037

化学结构图

9002-01-1
SMILES: O=C(O)C1CC(C2CCCCC2)CN1

别名和识别编码

Synonym Streptase Kabikinase Streptococcal fibrinolysin Streptokinase 来源于溶血性链球菌 Streptokinase 来源于 β-溶血性链球菌 （兰斯费氏菌 C 群） Streptokinase Awelysin
MDL NumberMFCD00082037
CAS Number9002-01-1
Chemical Name TranslationStreptokinase
Chemical NameStreptokinase from beta-hemolytic Streptococcus (Lancefield Group C) lyophilized powder, >=3,000 units/mg solid
EC Number232-647-1
PubChem Substance ID9815560
InChIInChI=1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
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分类

  • {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Coagulation Proteins and Reagents, Enzyme Class Index, Plasma & Blood Pr
  • {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Coagulation Proteins and Reagents, Enzyme Class Index, Plasma & Blood Proteins, Plasmin, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Related Products, Selective Proteolytic Enzymes, Serum Proteins and Related Enzymes, Serum Related Enzymes, Streptokinase, Therapeutic Enzymes, 生化试剂, 蛋白质及衍生物, 酶、抑制剂和底物

相关文献及参考

  • Bull. Wld. Hlth. Org. 33 , 235, (1965)
  • Hacke W, Ringleb P, Stingele R., Update in thrombolytic therapy. Rev. Neurol. (Paris) 155 , 662-665, (1999)
  • Bouros D, Schiza S, Siafakas N, Fibrinolytics in the treatment of parapneumonic effusions. Monaldi Arch. Chest Dis. 54 , 258-263, (1999)
  • Barletta JF., Streptokinase and urokinase for the treatment of pleural effusions and empyemas. Pharmacotherapy 33 , 495-498, (1999) 摘要
  • Merck 14 ,8825

安全信息

WGK Germany3
Hazard Codes B
RTECSOB8880000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 562500 iu/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   252,1314,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FOHEAW Folia Haematologica (Leipzig).  (Buchexport, Postfach 160, Leipzig
   DDR-7010, Ger. Dem. Rep.) V.32-    1926-  Volume(issue)/page/year:
   103,445,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 600 iu/kg
TOXIC EFFECTS :
   Immunological Including Allergic - uncharacterized
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   252,1314,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FOHEAW Folia Haematologica (Leipzig).  (Buchexport, Postfach 160, Leipzig
   DDR-7010, Ger. Dem. Rep.) V.32-    1926-  Volume(issue)/page/year:
   103,445,1976

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Proteolytic Enzymes and Substrates - Enzymes, Inhibitors, and Substrates
  5. Proteolytic Enzymes - Proteolytic Enzymes and Substrates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Blood - Immune Cell Signaling and Blood
  6. Clotting Factors - Blood
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Proteolytic Enzymes and Substrates - Enzymes, Inhibitors, and Substrates
  5. Selective Proteolytic Enzymes - Proteolytic Enzymes and Substrates
  6. Streptokinase - Selective Proteolytic Enzymes

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