(E)-N-(2-Aminophenyl)-3-(1-((4-(1-Methyl-1H-Pyrazol-4-Yl)Phenyl)Sulfonyl)-1H-Pyrrol-3-Yl)Acrylamide (E)-N-(2-氨基苯基)-3-[1-[[4-(1-甲基-1H-吡唑-4-基)苯基]磺酰基]-1H-吡咯-3-基]-2-丙烯酰胺
CAS 910462-43-0 MFCD010462430
化学结构图
SMILES: Cc1ccc(S(=O)(=O)O)cc1.Cn1cc(-c2ccc(S(=O)(=O)n3ccc(/C=C/C(=O)Nc4ccccc4N)c3)cc2)cn1
化学属性
| Mol. Weight | 447.51 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (E)-N-(2-氨基苯基)-3-[1-[[4-(1-甲基-1H-吡唑-4-基)苯基]磺酰基]-1H-吡咯-3-基]-2-丙烯酰胺 |
|---|---|
| Chemical Name | (E)-N-(2-Aminophenyl)-3-(1-((4-(1-Methyl-1H-Pyrazol-4-Yl)Phenyl)Sulfonyl)-1H-Pyrrol-3-Yl)Acrylamide |
| Formula | C23H21N5O3S |
| Synonym | 4SC202; 4SC-202; 4SC 202; domatinostat; |
| IUPAC Name | (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. |
| InChIKey | IAVXAZDVNICKFJ-ICSBZGNSSA-N |
| InChI | InChI=1S/C23H21N5O3S.C7H8O3S/c1-27-16-19(14-25-27)18-7-9-20(10-8-18)32(30,31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-16H,24H2,1H3,(H,26,29);2-5H,1H3,(H,8,9,10)/b11-6+; |
| Canonical SMILES | O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2.O=S(C5=CC=C(C)C=C5)(O)=O |
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产品应用
- 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.
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