Benzidine 联苯胺

CAS 92-87-5 MFCD00039765

化学结构图

92-87-5
SMILES: Nc1ccc(-c2ccc(N)cc2)cc1

化学属性

Mol. FormulaC₁₂H₁₂N₂
Mol. Weight184.24
Melting Point127-128°C
Boiling Point
Density1.25
SolubilitySoluble in water (0.32 mg/ml at 25 °C), DMSO, methanol, alcohol, and ether.
Stability对光线敏感
Flash Point-

别名和识别编码

Chemical NameBenzidine
CAS Number92-87-5
Alfabeta NameBIPHENYLDIAMINE 1144---,,''
MDL Number-
Synonym (1,1'-Biphenyl)-4,4'-diamine (1,1'-Biphenyl)-4,4'-diamine 1,1'-biphenyl-4,4'-diamine 4'-Amino-[1,1'-biphenyl]-4-ylamine 4,4'-Bianiline 4,4'-Biphenylenediamine 4,4'-Diamino-1,1'-biphenyl 4,4'-Diaminobiphenyl 4,4'-Diaminodiphenyl 4,4'-Diphenylenediamine 4,4'-biphenyldiamine 4,4'-Bianiline 4,4'-Biphenyldiamine 4,4'-Biphenylenediamine 4,4'-Diamino-1,1'-biphenyl 4,4'-Diaminobiphenyl 4,4'-Diaminodiphenyl 4,4'-Diphenylenediamine 4-(4-Aminophenyl)aniline p,p'-Bianiline p,p'-Diaminobiphenyl p-diaminodiphenyl Benzidin Benzidina Benzidine Benzidine, 9 Benzidine, 95%
PubChem Substance ID24869744
EC Number202-199-1
Beilstein Registry Number0742770
Chemical Name Translation联苯胺
InChIKeyHFACYLZERDEVSX-UHFFFAOYSA-N
Wiswesser Line NotationZR DR DZ
LabNetwork Molecule IDLN00140954
Canonical SMILES-
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分类

  • A-B, Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Aryl Amines MAK III, Category 1, B, BA - BH, Benzidines, Chromatography, Environmental Standards, Method Specific, Oeko-Tex Standard 100, Volatiles/ Semivolatiles
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SA} B, Bioactive Small Molecules, Cell Biology, Hematology and Histology, Stains & Dyes, A to Z, Stains and Dyes
  • {SNA} B, Bioactive Small Molecules, Cell Biology, Hematology and Histology, Stains & Dyes, A to Z,

产品应用

  • 比色法测定各种氧化剂(CN-, NO2-, ClO3-, SO42-)，氧化性金属、过氧化物酶、氰化物和血液的检定。硫酸盐、钨酸盐、磷酸盐和糖分的测定。氧化还原指示剂。用于偶氮染料中间体，也作不溶偶氮染料的显色剂。
  • 标准溶液用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
  • 联苯胺（4,4′-二氨基联苯）是一种环境的药物毒素，具有增加癌症的风险。联苯胺，可以使用作为标准物质。联苯胺可用于其遗传毒性机制的研究。

相关文献及参考

  • Merck: 14,1077
  • Short: II/27C
  • Toropov, A., et al.: Chem. Biol. Drug Design, 73, 482 (2009),
  • Short: II/27B
  • Dairou, J., et al.: Toxicol. App. Pharmacol., 236, 366 (2009),
  • Merck: 14,1077 Beilstein: 13,IV,364

安全信息

Warnings IRRITANT 危化品目录(2015) 危险化学品
Hazard statements
  • H350 May cause cancer 可能致癌
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P313
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
WGK Germany3
Signal word Danger
Hazard Codes F,T T;N T,N
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSDC9625000
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
UN Number 1885
Storage condition -20 -20°C, Hygroscopic 密封保存。 密封避光保存。 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25560 ng/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   EKSODD Eksperimental'naya Onkologiya.  Experimental Oncology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Mosow, USSR)  V.1-    1979-
   Volume(issue)/page/year: 9(4),73,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 10(5),50,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 315 mg/kg/34W
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 69,68,1970

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1620 gm/kg/45W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  F

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 58,167,1907

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 58,167,1907

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 309 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 54,101,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 400 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 3 mmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,267,1985

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 160 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,528,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 567 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - dog Cells

其他信息

  • 不溶于冷水，溶于热水，易溶于乙醇、乙醚。露置空气中或光线影响下颜色变深。1g溶于5ml沸乙醇、50ml乙醚、107ml沸水、2500ml冷水。其蒸气易被皮肤吸收。中等毒，半数致死量(大鼠，经口)309mg/kg。有致癌可能性。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. B - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains & Dyes, A to Z - Stains and Dyes
  5. B - Stains & Dyes, A to Z
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Amines - Chemical Class
  5. Aromatics - Amines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BA - BH - B
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. Oeko-Tex Standard 100 - Method Specific
  5. Aryl Amines MAK III, Category 1 - Oeko-Tex Standard 100

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