5-AIQ HYDROCHLORIDE

CAS 93117-07-8 MFCD03452659

化学结构图

93117-07-8
SMILES: Cl.NC1=CC=CC2C(=O)NC=CC=21

化学属性

Mol. FormulaC9H9ClN2O
Mol. Weight196.63

别名和识别编码

Chemical Name5-AIQ hydrochloride
Synonym 5-Aminoisoquinolinone hydrochloride
MDL NumberMFCD03452659
PubChem Substance ID24724396
CAS Number93117-07-8
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分类

  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, P to Q, PARP Poly(ADP-ribose) Polymerase, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
  • {SNA} A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q, PARP Poly(ADP-ribose) Polymerase

相关文献及参考

  • Rajesh, M., et al., Poly(ADP-ribose)polymerase inhibition decreases angiogenesis Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006)
  • Li, M., et al., Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells Pathobiology 76 , 108-16, (2009)
  • Nicolescu, A.C., et al., Inhibition of matrix metalloproteinase-2 by PARP inhibitors Biochem. Biophys. Res. Commun. 387 , 646-50, (2009)
  • Di Paola, R., et al., Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. Eur. J. Pharmacol. 492 , 203-210, (2004) 摘要
  • Cuzzocrea, S., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem. Pharmacol. 63 , 293-304, (2002)
  • McDonald, M.C., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br. J. Pharmacol. 130 , 843-850, (2000)

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. PARP Poly(ADP-ribose) Polymerase - P to Q

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